Lec1-3 Overview and Innate Immunity Flashcards Preview

Immunology > Lec1-3 Overview and Innate Immunity > Flashcards

Flashcards in Lec1-3 Overview and Innate Immunity Deck (23):
1

What is mech of multiple slcerosis

- immune attack against myelin basic sheet that insulates neurons

2

Is innate or adaptive immune more specific

adaptive

3

Is there more diversity in receptors of innate or adaptive?

Adaptive - due to somatic recombination of gene segments

4

What are 5 main components of innate immunity?

- barriers to infection [epithelium/skin]
- phagocytes
- dendritic cells
- NK cells
- complement

5

What make cell type make up pus?

neutrophils

6

What is principle function of B lymphocytes in immune

- mediate humoral immunity

7

What is the principle function of T lymphocytes in immune

Mediate cell-mediated immunity

8

Are natural killer cells in innate or adaptive immune?

innate

9

What is the principle fcuntion of dendritic cells in immune?

= act as antigen presenting cells, initiated T cell response

10

What is the principle function of follicular dendritic cells?

- display antigens to B cells in humoral immune response

11

What types of barriers involved in innate immune

1. physical barrier to infection [skin]
2. killing of microbes by locally produced antibiotics
3. killing of microbes by intrapepithelial lymphocytes

also: resident flora, chemical barriers

12

Are neutrophils or macrophages short lived?

neutrophils!

13

What are PAMPS?

- pathogen associated molecular patterns
- recognized by toll like receptors (a type of pattern recognition receptor [PRR] ) on surface of DC/macrophage and trigger activation

14

Endpoint of TLR signalling cascade

Part of innate immune

1. increase expression cytokines/adhesion molec --> acute inflamation, stimulate adaptive immune

2. increase production IFN --> antiviral state

15

What are NLRs? Endpoint?

NLR = nod-like receptor
- release IL-B: fuel acute inflammation and fever

16

5 Characteristics of inflammation

- heat
- redness
- swelling
- pain
- loss of function

17

Macrophages as sentinels

- recognize pathogens or cell death product

18

2 Natural Killer Cell Functions

1. Nk cell sees infected cell ad kills it

2. NK cell binds macrophage that has phagocytosed molecule, releases IFN-gamma that activates macrophage to kill phagocytosed microbe

19

How are NK cells inhibited?

- inhibitory receptor on NK cell binds self class I MHC-self peptide complex on normal cell so not activated and does not kill
- when NK binds virus infected cell that has little class I MHC expressed, no inhibitory receptor so kills cell

20

3 Paths of complement activation

1. Alternative: microbe initiates activation
2. Classical: microbe bound to antibody initiates
3. Lectin: microbe bound to mannose-binding lectin initiates

21

Which pat of complement peptides gets deposited on the microbe?

C3b

22

What happens to C3 in complement?

- C3a breaks off and stimulates inflammation
- C3b is deposited on microbe and aids in phagocytosis

23

Type 1 Interferon [IFN] pathway? 3 Mechanisms of viral inhibition

- IFN produced by virus infected cell
- binds IFN receptor on uninfected cell
- Mechanisms of blocking viral replication
1. degrades viral DNA
2. inhibits viral gene expression
3. inhibits viral protein synthesis