LEC21: Osteoporosis and Physical Activity Flashcards
(46 cards)
What is osteoporosis?
A condition where blood calcium levels (i.e. calcium in the extracellular fluid) are depleted which leads to a loss of mineral mass from bones
Osteoporosis: when bone resorption (blank) bone deposition
Exceeds
What is bone resorption controlled by?
Osteoclasts
What is bone deposition controlled by?
Osteoblasts
When someone has osteoporosis, they will…
have weak and fragile bones and an increased risk of bone fractures
When an individual has osteoporosis, they will have (blank) without any obvious symptoms (‘the silent thief’)
Bone loss occur
What is bone mass?
Refers to the weight of the skeleton
What is bone mineral density?
Refers to the ratio of weight to the volume or area of the bones
What is the basic assumption of heavier bones
It means stronger bones
Approximately (blank) Canadians have osteoporosis
2 million
(blank) women and (blank) men have osteoporosis
1 in 4, 1 in 8
Can osteoporosis strike at any age?
Yes
What are the most common sites for fractures?
Wrist, shoulder, hip, and spine
What are the areas most commonly affected by osteoporosis?
Spine, wrist, hip
What do vertebral fractures in advanced osteoporosis look like?
Bones become thinner and weaker with osteoporosis. Overtime, bones in the spine can become thin and collapse causing a person to hunch over
The line of gravity due to a kyphotic deformity
In a normal spine, the forces are distributed equally on the surface of the endplate avoiding stress peaks. The kyphotic deformity creates asymmetrical loading of the endplate which increases the risk of further fractures and increasing deformity
“wedge fractures”
“dowager’s hump”
What are factors affecting bone mineral density gains in childhood and adolescence
Genetics, mechanical forces, risk factors, nutrition, hormones, gender
Change peak bone mass (account for 60=80% of the peak bone mass variance)
Factors that affect calcium levels
- Dietary calcium
- Dietary vitamin D
- Alcohol intake
- Smoking
- Regular exercise
- Estrogen
Factors that affect calcium levels: dietary vitamin D
“Osteoporosis Canada’s new guidelines (July 2010)
- Recommended daily supplements of 400 to 1000 IU for adults under age 50 without osteoporosis
- For adults over 50, supplements of between 800 and 2000 IU are recommended.
- A daily supplement of 800 IU should be regarded as a minimum dose for all adults with osteoporosis.”
Factors that affect calcium levels: alcohol intake
A diuretic that causes calcium to be excreted in the urine
Factors that affect calcium levels: smoking
Decreases activity of osteoblasts
Factors that affect calcium levels: regular exercise
Weight bearing or resistance training makes bone respond (activates osteoblasts)
Factors that affect calcium levels: estrogen
- Lack of estrogen decreases the ability of the intestines to absorb dietary calcium
- Lack of estrogen decreases the ability of the kidneys to reabsorb calcium
- Post-menopausal women – calcium levels in the extracellular fluid (ECF) are low – bone resorption occurs to try to bring the ECF calcium levels back to normal
Effects of exercise and calcium intake on BMD in post-menopausal women
Most effective when taking calcium and having exercise