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MSK Exam 2 > Lecture 10: Cartilage Histology > Flashcards

Lecture 10: Cartilage Histology Flashcards

1
Q

What distinguishes one type of cartilage from another?

A

The Extracellular Matrix differs between types

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2
Q

What structures does cartilage lacks supply from?

A

Nerves

Blood Vessels

Lymphatics

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3
Q

What secretes the cartilage matrix?

A

Chondroblasts

Has mitotic capabilities

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4
Q

Where do chondrocytes come from?

A

Chondroblasts

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5
Q

What do you call a group of several chondrocytes in close proximity to each other?

A

An Isogenous Group

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6
Q

What is the structure that chondrocytes are housed in?

A

Lacunae: hollow space in the extracellular matrix of cartilage

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7
Q

What type of fibers is found in the cartilage matrix?

What is the most common

A
  • Type II Collagen (most predominant)
  • Type I Collagen
  • Elastin Fibers (elastic cartilage)
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8
Q

Where does cartilage arise from?

A

Embryonic Mesenchyme

Differentiation takes places from center to outward

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9
Q

What is the role of perichondrium?

A
  • Essential from growth and maintenance of cartilage
  • Holds the cartilage in place
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10
Q

What kind of connective tissue is the perichondrium?

A

Dense irregular connective tissue

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11
Q

What types of cartilages has a perichondrium?

Which types lack it?

A

Perichondrium Present:

  • Hyaline Cartilage
  • Elastic Cartilage

Perichondrium Absent

  • Hyaline Articular Cartilage
  • Fibrocartilage
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12
Q

What are the characteristics of the fibrous (outer) layer of the perichondrium?

A

Produces Type 1 collagen and fibroblasts

Acts as a transitional zone

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13
Q

What are the characteristics of the chondrogenic (inner) layer of the perichondrium?

A
  • Adjoins cartilage matrix
  • Contains mesenchymal stem cells that have chondroblasts that can differentiate into chondroblasts
  • Secretes Type II collagen
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14
Q

What has a vascular supply, which then allows the cartilage nearby to gain some nutrients?

A

The perichondrium

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15
Q

During periods of cartilage growth, where do new cartilage cells come from?

A

The perichondrium

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16
Q

Hyaline Cartilage

What type of collagen does it use?

Where is it found?

A

Type II collagen

Found in: Articular Cartilage, Larynx, Trachea, Ribs, Embryonic Developlment

17
Q

What is the hyaline matrix composed of?

A

Territorial Matrix

Interterritorial Matrix

Gives it a glassy, opaque look

18
Q

What is the epiphyseal plate made of?

A

Hyaline Cartilage

19
Q

What is the Territorial Matrix?

What molecule is it rich in?

What molecule does it have less of?

A

The more intensely stained portion of cartilage around any given isogenous group.

Rich in Glucosaminoglycans [GAGs]

Less Type II Collagen

20
Q

What is the Interterritorial Matrix rich in?

What does it have fewer of?

A

Type II Collagen

Proteoglycans

Less intense staining

21
Q

Elastic Cartilage

What type of collagen does it use?

Where is it found?

A

Type II Collagen and Elastin

Found in: External Ear, Epiglottis, Auditory tube

22
Q

Fibrocartilage Cartilage

What type of collagen does it use?

Where is it found?

A

Type I Collagen (Little Type II)

Found in: Intervertebral discs, pubic symphysis, and selected joint capsules

23
Q

What is the purpose of Fibrocartilage?

A

Withstands compression and shearing forces

24
Q

What is Fibrocartilage made up of in the most basic sense?

A

Hyaline cartilage and Dense Regular connective tissue

25
Q

What is interstitial growth?

A

Mitotic division of preexisting chondrocytes in lacunae

Adding volume

26
Q

What is appositional growth?

A

Chondroblast differentiation from progenitor cells in perichondrium

27
Q

Where do we see type 1 collagen in cartilage?

A

Fibrocartilage

Outer perichondrium

28
Q

How is repair cartilage different than other types?

What kinds of collagen does it contain?

What other tissue does it stimulate?

A

It is an intermediate between Hyaline and Fibrous Cartilage

Types 1 and 2

Facilitates bone healing - but can cause bone spurs

29
Q

What lines the ends of bones where they meet inside of an articular capsule?

A

Articular Cartilage

(Hyaline Cartilage with no perichondrium)

MSK Exam 2 (22 decks)

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