Lecture 10: Poxviruses, papillomaviruses, African Swine fever

Question 1

What are some examples of orthopoxviruses

Answer 1

1. Camelpox
2. Monkeypox

Question 2

what are some examples of capripoxviruses

Answer 2

1. Sheep/goat pox
2. Lumpy skin disease

Question 3

what are some examples of leporipoxviruses

Answer 3

rabbit myxoma virus

Question 4

what poxviruses are the foreign animal diseases

Answer 4

1. Camelpox
2. Monkeypox
3. Sheep/goat pox
4. Lumpy skin disease
5. Rabbit myxoma virus

Question 5

poxviruses are the largest viruses >__nm

Answer 5

200

Question 6

In poxviruses where does DNA replication occur

Answer 6

in cytoplasm

Question 7

what is the main clinical sign of poxviruses

Answer 7

vesicles and scabbing

Question 8

what this, what is an important differential

Answer 8

Dx: bovine papular stomatitis

Important ddx: FMD

Question 9

T of f: bovine papular stomatitis is only in U.S.

Answer 9

false- worldwide distribution

Question 10

T or F: bovine papular stomatitis is zoonotic

Answer 10

true

Question 11

what this

Answer 11

orf/contagious ecthyma

Question 12

T or f: orf/contagious ecthyma has worldwide distribution

Answer 12

true

Question 13

what wrong and what type of virus

Answer 13

Myxomatosis
Pox virus

Question 14

what wrong

Answer 14

lumpy sign disease

Question 15

What pox virus is this. from sheep

Answer 15

sheep/goat pox

Question 16

what lesions are associated with sheep and goat pox

Answer 16

dermal/pulmonary

Question 17

what this

Answer 17

Camelpox

Question 18

t or f: Camelpox is a foreign animal disease in old world camelids

Answer 18

true

Question 19

how are poxviruses transmitted

Answer 19

1. Aerosol
2. Vector- mechanical
3. Direct contact
4. Fomites

Question 20

What is tx for poxviruses

Answer 20

palliative care

Question 21

how are poxviruses prevented and controlled

Answer 21

1. Vaccination
2. Control mechanical vectors
3. Isolation/slaughter

Question 22

what tissue does cowpox target

Answer 22

oral mucosa

Question 23

how is cowpox transmitted

Answer 23

contact, fomites, vectors

Question 24

is cowpox a FAD and zoonotic

Answer 24

not FAD, yes zoonotic

Question 25

is orf a FAD and zoonotic

Answer 25

not FAD, yes zoonotic

Question 26

what tissue does orf target

Answer 26

oronasal mucosa

Question 27

how is orf transmitted

Answer 27

contact, fomites, vectors

Question 28

is myxomatosis a FAD and zoonotic

Answer 28

yes FAD, not zoonotic

Question 29

what does myxomatosis target

Answer 29

skin, lymphocytes

Question 30

how is myxomatosis transmitted

Answer 30

contact, fomites, vectors

Question 31

is lumpy skin disease a FAD and zoonotic

Answer 31

yes FAD, no zoonotic

Question 32

where does lumpy skin disease target

Answer 32

skin

Question 33

how is lumpy skin disease transmitted

Answer 33

contact, fomites, vectors

Question 34

is sheep/goat pox a FAD and zoonotic

Answer 34

yes FAD, not zoonotic

Question 35

where does sheep/goat pox target

Answer 35

skin, URT/LRT

Question 36

how is sheep/goat pox transmitted

Answer 36

contact, fomites, vectors

Question 37

is Camelpox an FAD and is it zoonotic

Answer 37

yes FAD, zoonotic but rare

Question 38

where does Camelpox target

Answer 38

skin, URT/ LRT

Question 39

how is Camelpox transmitted

Answer 39

contact, fomites, vectors

Question 40

is sealpox an FAD and zoonotic

Answer 40

not FAD, yes zoonotic

Question 41

where does sealpox target

Answer 41

skin, mucosa

Question 42

how is sealpox transmitted

Answer 42

contact, fomites

Question 43

poxviruses replicate in the __, most commonly in __ tissues

Answer 43

cytoplasm, dermal/mucosal tissues

Question 44

what is the cause of equine sarcoidosis

Answer 44

bovine papilloma virus

Question 45

how do papillomaviruses get into cells

Answer 45

endocytosis within basal squamous epithelial cells

Question 46

what are the clinical signs of papillomaviruses

Answer 46

proliferative lesions (warts) of the epithelium

Question 47

what virus caused this

Answer 47

Papillomavirus

Question 48

what is tx for papillomavirus

Answer 48

1. Excision 2. Cryosurgery 3. Radiation, chemo 4. Spontaneous regression

Question 49

how and where do papillomaviruses replicate and how does that help them evade immune system

Answer 49

within nucleus of epithelial cells, through a non-lytic process which avoids triggering the immune system

Question 50

Where was African swine fever found 1921-2007

Answer 50

african subcontinent

Question 51

where is African swine fever found from 2007- present

Answer 51

eastern, Western Europe, Asia, Haiti, DR

Question 52

African swine fever is the only known DNA virus with ___

Answer 52

biological arthropod vector

Question 53

what are the per acute clinical signs of African swine fever

Answer 53

sudden death

Question 54

what are the acute signs of African swine fever and mortality

Answer 54

fever, ADR, cutaneous hemorrhage, splenomegaly High mortality

Question 55

what are the signs of subacute African swine fever and mortality

Answer 55

pneumonia, weight loss, joint swelling, ADR Variable mortality

Question 56

how is African swine fever transmitted

Answer 56

tick borne, contact with infected swine or pork products

Question 57

what is the treatment and prevention for African swine fever

Answer 57

1. Depopulation/ decontaminate/ repopulate 2. Prevent exposure to wild or feral swine, insect vectors

Question 58

there are no effective vaccines for African swine fever, it is __incompatible

Answer 58

DIVA

Question 59

what does DIVA mean

Answer 59

ability to distinguish infected from vaccinated animals- requirement for effectively separating true infections from animals which have been vaccinated in endemic areas