Lecture 11- Immune system induced diseases 1 Flashcards Preview

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Flashcards in Lecture 11- Immune system induced diseases 1 Deck (10):
1

What is primary immunodeficiency?

It is a defect in one or more components of the immune system (either innate or adaptive systems). They typically do not show until they are needed.

2

What is the major clinical sign that indicates PID?

Constant infections and abnormal responses to microbes.

3

What are the three types of primary immunodeficiency?

Antibody deficiencies, t-lymphocyte deficiencies and innate deficiencies

4

What is Common Variable Immunodeficiency (CVID)?

It is a B-cell malfunction in which the cells fail to differentiate into the plasma cells. As a result, no antigens are produced at all.

5

What is the treatment for CVID?

Immunoglobulin replacement therapy (antibody transplants) and antibiotics.

6

what is specific antibody deficiency?

It is a deficiency in a certain antibody, IgG 2. This results in no protection from polysaccharide antigens.

7

What is the major pathological outcome from having specific antibody deficiency?

They get infections from the polysaccharide antigen, streptococcus pneumoniae. This results in pneumonia.

8

what is severe combined immunodeficiency?

It is very rare, but it basically involves a lack of B and T-cells in the body. This causes severe susceptability to infections and requires strong isolation from the environment (bubble boy).

9

What is IPEX syndrome?

It is a lack of the Treg cells in the immune system. This results in an absence of small bowel mucosa and inflammatory infiltrate in many organs.

10

What is IRAK-4 deficiency?

It is a deficiency in the interleukin-1 receptor associated kinase 4. This results in impaired T-cell activated.