lecture 11 infalmmation Flashcards
acute inflammation cell
neutraphil
chronic inflammation cell
lymphocytes, plasma cells and macrophages
fluid that leaves vessels
exudate
what can exudate go on to form
puss
two breakdown products of C3
attracts phagocytes
mast cells produce mediators of inflammation
inflammatory thing platelets produce
serotonin
arachoidonic metabolites
prostoglandins and leukotrienes
what type of molecule are prostoglandins and leukotrienes
lipid
two main pathways of arachidonic metabolism
ox pathways and lipo-oxygenase pathway
what pathway way does aspirin interfere with
ox
what pathway do steroids interfere with
lipo-oxygenase
what can respond to platelet activating factor
macrophages
platelets
what do activated platelets target
endothelial cells
what are the mediators of fever response
pyrogens
endogenous pyrogens produced during inflammation
cytokines
exogenous pyrogens e.g.
LPS
congestion
bacteria cause outpouring of protein rich fluid
consolidation
neutrophils and red cells enter alveolus, fluid and cell spread to adjacent alveoli leading to solidification
Grey hepatization
Macrophages recruited and eat dead neutrophils and begin digestion of fibrin mesh
Organization
scar formation due to loss of structural integrity
example of acute inflammation becoming chronic
abscess
abscess is an accumulation of what
neutrophils
main difference between chronic and acute
cell type
formation of foreign body macrophages
lots of macrophages coming together
