lecture 12 Flashcards
opioids, ethanol, barbiturates, and BZD all work in what part of the brain?
ventral tegmental area
amphetamines, cocaine, opioids, cannabis, and phencyclidine all work in what part of brain
nucleus acumbens
DA releasee in NA promotes what
desire and pleasure
VTA involved in what
rewarding motivation of addictive drugs
psychostimulants work at the level of what? and targets what?
presynaptic. DAT and VMAt
endorphins bind to which receptor?
mu
enkephalins bind to which receptor?
delta
opiates bind to what?
gaba
nicotine binds to what?
opiod peptide to increase release and DA to increase release
cannabinoids do what and bind where?
inhibit gaba in VTA
what drug is released from postsynaptic and goes back into pre synaptic which then goes to C1?
cannabinoids
alcohol does what and acts where?
on opioid peptide to increase opioids release to inhibit gaba. works at Da in VTA and at post synaptic area to increase dopmaine
progression of drug dependence goes from _______ to ________ reinforcement.
positive to negative
the negative effect state characterized by presence of what motivational signs?
chronic irritability, emotional pain, malaise, and dysphoria.
withdrawal state is a __________ process from __________ dependence
dissociable, somatic/physical
