lecture 12 Flashcards by darin daw

Q

cancer proprities

A

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Q

properities of cancer cell

A

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Q

cancer cell loss

A

contact inhibition and have altered morphology

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Q

cancer caused by

A

accumulation mutation that activated oncogenes and inhibit tumor suppressores

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Q

single transduction pathway

A

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Q

scr functions downstream of integrins factor recptor

A

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Q

ras

A

bladder carcinoma

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Q

met oncogene

A

hepatocarcinoma

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Q

hst

A

stomach carcinoma

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Q

erb b

A

breast cancer

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Q

ras GTPNGDP CYCLE

A

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Q

RAS DO

A

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Q

HOW ARE PROTO ONCOGENE CONVERTED TOONCOGENES

A

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Q

C MYC IS OFTEN OVER EXPRESSED DUE TO

A

CHROMOSOMAL TRANSLOCATION

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Q

C MYC IS TRANSCRIPTION FACTOR

A

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Q

CELL cycle progression is controlled by

A

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Q

control of G1 to s phase movement

A

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Q

the restriction point is controlled by phosphorylation of pRb

A

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Q

p53 is tumor supporessor

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A

Q

p53 is actived when

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A

Q

the oncogenic checkpoint

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A

Q

the hallmarks of cnacer

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Q

sustaining proliferative signaling

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A

Q

dna turmor viruses target pRB and p53

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A

evading growth suppressor

resisting cell death

caspase targets

two major apoptotic pathways

resisting cell death

the death recptor pathway

the basic Extrinsic apoptotoic pathway

the mitochondrial intrinsic pahtway

apoptosis controlled by the balance of

proapoptotic and prosurvivial factors at the mitochondria

the mitochondrial apoptotic pathway

BCL2

inducing angiogensisi

angiogensisi is controlled by

limitless preplicative potential

telomer lenght vs cell divisons

telmomeres is

telomerase and dna replication

enter telomerase

transcriptional control of metastasis in cancer

altered metabliism

aktoncogene

lifesthle choices decrease cancer