Lecture 14: Drugs affecting Hemostasis

Question 1

which cholesterol meds interact with clotting?

Answer 1

fibric acid derivatives like clofibrate, fenofibrate, and gemfibrozil may inhibit coagulation and enhance fibrinolysis

Question 2

lab tests for coagulation (PTT, PT/INR, TT)

Answer 2

Partial Thromboplastin Time
- measures efficacy of intrinsic and common pathways
- normally 25-30 seconds but will be 120 sec + for a clot to form if someone is on heparin
- to test someone on heparin or direct thrombin I

Prothrombin Time/ INR
- dependent on vit K, for testing warfarin

Thrombin Time
- time for fibrinogen to turn to fibrin (via thrombin)