Lecture

Question 1

Controlled by vessel Smooth Muscle, enhanced by chemicals, secreted by platelets

Answer 1

Vasoconstriction

Question 2

To exposed subendothelial connective tissue

Answer 2

Platelet Adhesion

Question 3

Interaction and adhesion of platelets to one another to form initial plug at the site of injury

Answer 3

Platelet Aggregation

Question 4

Coagulation factors interact on platelet surface to produce fibrin

Answer 4

Fibrin-Platelet Plug Formation

Question 5

Fibrin clot must be stabilized by coagulation factor XIII

Answer 5

Fibrin Stabilization

Question 6

What are the Primary Phase of Homeostasis??

Answer 6

Vasoconstriction
Platelet Adhesion
Platelet Aggregation

Question 7

What are the Secondary Phase of Homeostasis??

Answer 7

Fibrin-Platelet Plug Formation
Fibrin Stabilization

Question 8

Physiological Response that is/are included in Neuro-Muscular Response

Answer 8

Vasocontriction

Question 9

Physiological Response that is/are included in Platelet Activation

Answer 9

Adhesion release
Reaction Aggregation

Question 10

Physiological Response that is/are included in Coagulation

Answer 10

Intrinsic PW
Extrinsic PW
Common PW

Question 11

Physiological Response that is/are included in Fibrinolysis

Answer 11

Plasminogen
Tissue Plasmin Activator
Plasmin

Question 12

What type of Blood Vessel is for metabolic exchanges to diffusion?

Answer 12

Capillaries

Question 13

What Blood Vessel is “oxygenated”?

Answer 13

Arteries

Question 14

What Blood Vessel is “deoxygenated” to valves?

Answer 14

Veins

Question 15

How many hours that Veins consume in valves?

Answer 15

8 hours

Question 16

What substance that inhibits platelet adhesion and aggregation and stimulates vasodilation?

Answer 16

Prostacyclin (Prostaglandin I2)

Question 17

What substance is only stimulates vasodilation?

Answer 17

Adenosine
(Metabolic product of ATP to ADP)

Question 18

What substance that destroy ADP and limits the platelet activation?

Answer 18

ADPase

Question 19

What substance that has endothelial Cell Receptor for thrombin?

Answer 19

Thrombomodulin

Question 20

What substance that binds and inactivates thrombin and enhances anticoagulant and fibrinolytic action of Protein C found in the plasma?

Answer 20

Thrombomodulin

Question 21

A substance that has an action that coats the endothelial cell surface and weakly enhances the activity of antithrombin III

Answer 21

Heparan sulfate

Question 22

A substance that has an action of Plasma Anticoagulant

Answer 22

Heparan Sulfate

Question 23

A substance that converts Plasminogen to Plasmin

Answer 23

Tissue Plasminogen Activator

Question 24

A substance that is released only on appropriate stimulus, such as vessel injury, to prevent excessive clot formation.

Answer 24

Tissue Plasminogen Activator

Question 25

A substance that has regulatory protein for fibrinolytic system

Answer 25

Plasminogen Activator Inhibitor-1

Question 26

A substance that protein produced in endothelium and stored in subendothelium (in the form of Weibel-Palade bodies) before secretion into the plasma and attachment to factor VIII: C

Answer 26

Von Willebrand Factor (vWF)

Question 27

It is a cytoplasmic fragments of the megakaryocytes

Answer 27

Platelets

Question 28

What are the functions of platelets in hemostasis?

Answer 28

1. Adhesion to injured vessels 2. Aggregation at the site of the injury site 3. Promotion of Coagulation on their Phospholipid surface 4. Release of biochemicals important to hemostasis from their alpha and dense bodies 5. Induce clot retraction

Question 29

What are the Dense Granules?

Answer 29

ADP Calcium Serotonin

Question 30

What are the Membrane Phospholipids?

Answer 30

Thromboxane A2 Precursor

Question 31

Endoreduplication is regulated by what gene?

Answer 31

RUNX-1

Question 32

Progressive nuclear lobulation, includes DNA content, without cytoplasmic division.

Answer 32

Polyploidization

Question 33

What are the Factors Influencing Megakaryopoiesis?

Answer 33

•Early Acting Multilineage cytokines •More Specific Cytokines

Question 34

What are the Terminal Megakaryocyte Differentiation Stages?

Answer 34

Morpholigically recognizable Wright-stained Bone Marrow aspirate Hematoxylin & Eosin Bone Marrow biopsy

Question 35

MK-I is also known as

Answer 35

Megakaryoblast

Question 36

Promegakaryocyte is also known as

Answer 36

MK-II

Question 37

MK-III is also known as

Answer 37

Megakaryocyte