Lecture 2 & 3 Antipsychotics

Question 1

DSM Criteria for Psychosis

Answer 1

Delusions - A fixed-false belief
Hallucinations - Perceptions that are not real
Disorganized Speech
Disorganized behaviors
Negative Symptoms

Question 2

Time line for Brief Psychotic Episode

Answer 2

1 day to less than 60 days

Question 3

Time line for Schizophreniform

Answer 3

Greater than 6 months

Question 4

Time line for Schizophrenia

Answer 4

more that 6 months

Question 5

Dopamine Hypothesis

Answer 5

Too much dopamine in the limbic system.
Too little dopamine in the frontal cortex

Question 6

Mesolithic Pathway - Limbic System

Answer 6

To much dopamine
Positive Symptoms

Question 7

Mesocortical Pathway - Prefrontal Cortex

Answer 7

Too little dopamine
Negative Symptoms

Question 8

First Generation Antipsychotics Neuro Function

Answer 8

Blocks Dopamine - D2 Receptor
High Potency - Binds to D2 strongly
Low Potency - Bind less to D2

Question 9

First Generation Antipsychotics Side effects

Answer 9

Dystonia - muscle spams
Pseudoparkinsonism - tremor, rigidity, shuffling gait
Tardive dyskinesia - odd movements, lip smacking
Akathisia - feeling the need to move

Question 10

First Generation Antipsychotics
High Potency Medications

Answer 10

Haloperidol (Haldol)
Fluphenazine (Prolixin)

Question 11

First Generation Antipsychotics
Low Potency Medications

Answer 11

Chlorpromazine (Thorazine)

Question 12

Second-Generation Antipsychotics Neuro Function

Answer 12

Blocks D2 and 5-HT2A

Question 13

Second-Generation Antipsychotics Medications (commonly used)

Answer 13

High Potency - Risperidone (Risperdal), Paliperidone (Invega)
Mid Potency - Olanzapine (Zyprexa), Ziprasidone (Geodon)
Low Potency - Quetiapine (Seroquel), Clozapine (Clozaril)

Question 14

Second-Generation Antipsychotics Side effects

Answer 14

Sedation
Weight gain
EPS