lecture 2 Flashcards

(42 cards)

1
Q

2 NS division

A

CNS

PNS

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2
Q

2 branches of PNS

A

somatic : coluntary
autonomic: involuntary.
Symp & parasym. complementary systems

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3
Q

who named the 2 autonomic systems? and why?

A

galen - names ymp because bodily organs were where emotions came from. para is next to symp.

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4
Q

what are a few functions of symp?

para?

A

dilate pupils, decrease salivation, decrease digestion, increase hr, increase bp.
P: digestion increase, repro increases.

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5
Q

symp NS.

when? other name? releases what hormone?

A

emergencies,
fight, flight, fright, sex
release A and NA

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6
Q

Para NS

when? other name? function?

A

calm acitivities
rest and digest
store energy & growth.

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7
Q

NT

A

chemical messenger

neuron to neuron communication

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8
Q

hormone

A

chemical messenger

far-reachin gcommunication.

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9
Q

Talk about peripheral gland and male sex drive

A

Thought each peripheral gland controlled its own hormone secretion (type and amount). Observed that older men = lower sex drive. Tried to inject testosterone from other animals = found more young, and viral men. Tried surgically grafting testicle from other animal onto man. = found good results here as well. GIANT PLACECBO. Testosterone was dissolved in water when injected = fat in water? Didn’t dissolve, didn’t even inject T.

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10
Q

pituitary gland

  • function
  • what was found when explanted?
A

regulated other glands

- when explanted secreted huge amount of unnecessary hormones. didnt function properly on its own.

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11
Q
the brain
- Harris & master gland. new idea?
circulatory system in brain?
who are the 2 scientists battling to find hormones in brain?
what area of brain invovled in hormones?
A
  • new idea = brain is master gland, “impure” because involves emotions, and involuntary actions
  • circulatory system between hypothalamus and pituitary. communicate with one another.
  • guillemin and schally. one synthesized hormone, other found structure but couldnt reproduce.
    hypothalamus of brain has effect on pituitary
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12
Q

4 classes of steroid classes

A
androgens
estrogens
progestogens
minerocorticoids
glucocorticoids
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13
Q

hromones secreted from body during stress

A

A, NA = takes seconds to act.

glucocorticoids, cortisol = takes mins/hours to work.

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14
Q

HPA axis for glucagon

A

Hypo = corticotropin releasing hormone (CRH)
Pit = adrenocorticotropic hormone (ACTH)
adrenal gland = glucocorticoids (cortisol)
Pancrease = glucagon

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15
Q

function of glucagon

A

released during stress response. mobilized stored glycogen = raise blood sugar

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16
Q

main function of stress response

A

increase glucose (energy) for muscles to continue working.

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17
Q

what 2 hormones does the pituitary secrete after stressor

A

prolactin, endorphin = suppressed repro and pain

18
Q

what groups of hormones are inhibited after stressor

A
  • repro hormones
    growth hormones
    insulin
19
Q

gender differences

A

females - usually take care of yound. cant fight, or flee. Use tend and befriend tactic.
males - protect young from distance, hunt, fight.

20
Q

tend and befriend

A

rely on social affiliation, females protect offspring collectively

21
Q

oxytocin - function in tend and befriend

  • what hormone increases oxytocin release?
  • function as mother?
  • other effects?
A

secreted by pituitary during stress.
- estrogen.
function in female imprinting on children; milk let down. influences maternal behaviour causing more receptors to be produced, baby behaviour encourages more oxytocin production = cycle.
other effect: increase trust, generosity, increase social bonds

22
Q

caveats to glucocorticoids and symp NS

A
  • speed and magnitude of release may vary. depends on intensity of stressor.
  • different tissue sensitivity to hormone
  • psychological context - subjective interpretation of stressor
23
Q

hormonal signature

A

speed and magnitude at which hormones change during stress response.

  • some ready to cope and react - more A/NA, less glucocorticoid.
  • some learned helpessness: less A/NA, more glucocort. = “cant deal”
24
Q

cardiovascular stress response

A

increase hr
increase force of heart beat = veins get more rigid.
arteries to muscles vasodilate.
kidneys reabsorb more water - keep blood volume high.
ADH - increase = more water reabsorbed.

25
why do veins get more rigid? | what does vasoconstriction cause?
veins get more rigid due to A. | vasoconstriction = higher bp
26
metabolic demand? | discrepancy btw blood flow?
demand that current situation is placing on muscles and blood. - sitting & worrying= greater discrepancy. harmful for body.
27
what is hypertension?
chronically elevated blood pressure
28
How heart disease effects - heart muscles - bifurcation poitns - cholesterol effects?
- left ventricular hypertrophy. more muscle because need more muscle to push blood thru, also lot of blood slamming heart, needs to protect. - branch points in cardio system. high pressure blood hitting branch point = v vulnerable. can get micro-tears. immune response causes migration of cells = can become plaque. - cholesterol affects if there is prior damage to cardio system
29
c-reactive protein (CRP) - secreted by? - function - b-blocker actions?
secreted by liver - amplify immune system cascade to repair body thats been damaged - b-block, prevents SNS activity. less plaque, couldnt activate symp.
30
``` define: embolus thrombus myocardial infarct brain infarct ```
- moving blood clot/ plaque - stationary blood clot - heart attack. embolud travels to coronary vessels = no O2 - stroke. embolus in vasculature feeding the brain
31
myocardial ischemia | angina pectoris
reduction in blood supply to heart. | - angina = really reduced blood flow to heart. may present as chest pain.
32
vagus nerve?
activated by PNS. link between resp and caridac. | - exhale - PNS. inhale = symp.
33
heart rate variability
change in HR when inhale vs exhale. c
34
sudden cardiac death
strong emotions. cardio system damaged, more sensitive to acute stressors.
35
ventricular fibrillation?
ventricles contact in rapid, disorganized way. SNS sends 2 asymmetrical projections to the heart.
36
women and heart disease - more or less heart attacks then men? - vulnerable to heart attack? Estrogen
- - less heart attacks than men. - more vulnerable when they do get heart attacks because they happen ~10 years later. harder to recover at older age. - estrogen has protective effect on cardio system. prevents cell build up at bifurcation.
37
psychophysiological death
dramatic version of sudden cardiac arrest | - due to overactive SNS, emotion, "scared to death"
38
insulin
stimulates transport and storage of molecules secreted in anticipation of meals PNS
39
Emergency - PNS vs SNS? - insulin vs glucagon? glucocorticoid action?
favours SNS glucagon : energy out. glucocoritcoid blocks insulin action. blocks storage of molecules.
40
chronic stress & metabolism - fatigue - fat and glucose in blood stream = ? - LDL vs HDL
get fatigued from storing and unstoring energy. - increase risk of cardiovascular disease - LDL - low density protein. more cholesterol, than protein. hard to transport bc not soluble in water. necessary for cell walls. - HDL - high density protein. can travel around body, but can't supply enough cholesterol to cells.
41
``` diabetes - type 1. other name? what caused it? result? effect of stress? ```
insulin-dependent immune cells attack insulin-secreting cells in pancreas. cells dont get energy, rise in blood sugar, clogged arteries. stress = cells become less senstiive to insulin
42
``` diabetes - type 2 other name? cause? result? effect of stress? ```
insulin-independent. adult onset - cells dont respond to insulin, produced but not used. feedback loop continues to increase insulin levels - pancreatic cells burn out, cells stop working = turns to type 1. Enough fat is stored - stress = more insulin resistance. exacerbates type 2 = greater blood glucose levels.