lecture 20-21

Question 1

Name the primary routes by which drugs are excreted from the body.

Answer 1

renal via kidney
biliary via feces
pulmonary
salivary
mammary

Question 2

Identify the key processes and anatomical location involved in renal excretion.

Answer 2

nephron of kidneys
glomerular filtration
active tubular secretion
tubular reabsorption
biotransformation

Question 3

Describe how the physiochemical properties of a drug influence its filtration, secretion, and reabsorption by the kidney.

Answer 3

molecular size (MW <5000)

Question 4

Plot the relationship between molecular weight and renal clearance.

Answer 4

as molecular weight increases, renal clearance decreases (downward liner plot)

Question 5

Plot the relationship between dose and urinary excretion rate for a drug that undergoes filtration only and one eliminated primarily through renal excretion.

Question 6

Plot the relationship between molecular weight and percent of drug excreted in bile.

Question 7

Describe the impact of enterohepatic recirculation on drug-half life in the body.