Lecture 23- Malaria Flashcards Preview

Block 4 - Heamatology > Lecture 23- Malaria > Flashcards

Flashcards in Lecture 23- Malaria Deck (33)
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31

Appropriate therapy requires

- identifying the species of malaria parasite
- estimating the level of parasitemia
- determining the immune status of the patient
- ascertaining the likely geographic origin of the infecting parasite

32

TREATMENT

- chloroquine and amodiquine
- quinine, quinidine
- artemisinin, artemether, artersunate
- mefloquine
- halofantrine
- Dihydrofolate reductase inhibitors
- dihydropteroate syntheses innhibitors
- primaquine
- tetracycline, doxycycline
- atovaquone

33

Chemoprophylaxis

- indicated for non immune persons entering malaria-endemic areas
- chemoprophylaxis may also be appropriate for certain high-risk groups living in endemic areas
- most prophylaxis do not prevent infection but aborts or modifies clinical attack
- most suitable for drugs of longer T1/2
- chloroquine phosphare is effective for infection caused by Vivas, ovale, malaria and chloroquine-sensitive strains of falciparum
- chloroquine resistant falciparum: artermether primary choice, doxcycline or the combination of atovaquone, proguanil are alternatives
- administration should be initiated before entering a malarous area and should be continued for 4 weeks after leaving