Lecture 24

Question 1

What is IL-10?

Answer 1

Anti-inflammatory cytokine

Question 2

What are IEL’s?

Answer 2

A type of CD8 T cell— intercalate INTO the intestinal epithelial cells without disrupting the barrier

Question 3

What are the features of intestinal macrophages?

Answer 3

Phagocytose bacteria and apoptotic cells, do not cause inflammation

Question 4

How do intestinal DC’s contribute to intestinal immune “calming”

Answer 4

They produce IL-10 in response to antigen uptake in the Peyer’s Patch

Question 5

Why do you want to decrease inflammation in the gut?

Answer 5

Severe inflammation in the gut is more likely to exacerbate the infection than
clear it, and is the cause of a variety of chronic human diseases.

Question 6

What is Fab and Fc?

Answer 6

Fab: antigen-binding fragments
Fc: non-antigen binding fragments (can crystallize)

Question 7

What are the three types of Fc receptors?

Answer 7

• transport antibody across membrane
• activation of cell function
• inhibition of a cell function

Question 8

What is the PigR?

Answer 8

Transport Fc receptor— binds to Fc regions of antibodies that have J chains and goes across the mucosal epithelial layer
- remains attached to the IgM/IgA as a secretory piece and binds to the mucosal layer