Cause of petechiae?
Endotoxin from G- bacteria
Meningitis cause in all ages?
Strep pneumo
N. meningitidis
Meningitis cause in 3mos-7yrs?
H. Influenza type B
Meningitis cause in neonates?
S. agalactiae
E. coli
Listeria monocytogenes
Strep pneumo+N. meningitidis
Meningitis treatment?
Cephalosporins
Fluid/Electrolyte
Corticosteroids
N. meningitidis vaccine against what?
capsular polysaccharide
N. meningitidis vaccine effective?
Yes, against capsule groups A, C, Y, and W135
N. meningitidis vaccine NOT effective?
capsule group B
most common killer today
non-immunogenic
N. meningitidis outbreak…give what?
Rifampin
Traps molecules >800 MW
Periplasm
Protein in PG layer of G-
LPS
Endotoxin=
LPS
Toxic part of LPS
Lipid A
non-immunogenic
Shared among Enterobacteriaceae (heptose + KDO)
Core Polysaccharide
Ag specific part of LPS
O somatic Ag
immunogenic
LOS
shorter O chain
Same effect as LPS cause has LPS
G- Outer membrane structures
Porins
Pili
Form of G- bacteria after losing MOST of cell wall
Spheroplasts
can sometimes regen
Endotoxin or Exotoxin?
G- only
endo
Endotoxin or Exotoxin?
Part of cell wall
endo
Endotoxin or Exotoxin?
LPS (not protein)
endo
Endotoxin or Exotoxin?
Lethal dose 1 micro g
endo
Endotoxin or Exotoxin?
Non enzymatic
endo
Endotoxin or Exotoxin?
non-variable genetic traits
endo
Endotoxin or Exotoxin?
G+ or G-
exo
Endotoxin or Exotoxin?
Secreted
exo
Endotoxin or Exotoxin?
Proteins
exo
Endotoxin or Exotoxin?
Lethal dose ng or pg
exo
Endotoxin or Exotoxin?
Enzymatic
exo
Endotoxin or Exotoxin?
Variable genetic traits
exo
Endotoxin or Exotoxin?
Enterotoxin
exo
bacteria in blood but no symptoms
bacteremia
bacteria in blood with symptoms
septicemia
Super Ag list
TSST-1
Enterotoxin B/C
SPE A/B/C
Pyrogenic and cause fever
IL-1beta and IL-6
Capillary leak and cause hypotension
TNF-alpha
Cause rash and T cell production
IL-2
Macrophage activation and rash cause
IFN gamma
G+ pathway to bacterial induced shock Causative agent: Receptor on Macrophage: IL-1b: TNF-a: IFN-g +IL-2: Lethal dose:
LTA TLR 2/6 IL 1b TNFa no 1mg
G- pathway to bacterial induced shock Causative agent: Receptor on Macrophage: IL-1b: TNF-a: IFN-g +IL-2: Lethal dose:
LPS TLR-4 IL 1b TNF a no 1 micro g
Super Ag pathway to bacterial induced shock Causative agent: Receptor on Macrophage: IL-1b: TNF-a: IFN-g +IL-2: Lethal dose:
Super Ag MHC-II/TCR cross link IL-1b TNF-a IFNg + IL-2 0.1 micro g
vBeta on TCR has ______ specificity
great