Lecture 3 - G- Flashcards Preview

PID > Lecture 3 - G- > Flashcards

Flashcards in Lecture 3 - G- Deck (42)
Loading flashcards...
1
Q

Cause of petechiae?

A

Endotoxin from G- bacteria

2
Q

Meningitis cause in all ages?

A

Strep pneumo

N. meningitidis

3
Q

Meningitis cause in 3mos-7yrs?

A

H. Influenza type B

4
Q

Meningitis cause in neonates?

A

S. agalactiae
E. coli
Listeria monocytogenes
Strep pneumo+N. meningitidis

5
Q

Meningitis treatment?

A

Cephalosporins
Fluid/Electrolyte
Corticosteroids

6
Q

N. meningitidis vaccine against what?

A

capsular polysaccharide

7
Q

N. meningitidis vaccine effective?

A

Yes, against capsule groups A, C, Y, and W135

8
Q

N. meningitidis vaccine NOT effective?

A

capsule group B
most common killer today
non-immunogenic

9
Q

N. meningitidis outbreak…give what?

A

Rifampin

10
Q

Traps molecules >800 MW

A

Periplasm

11
Q

Protein in PG layer of G-

A

LPS

12
Q

Endotoxin=

A

LPS

13
Q

Toxic part of LPS

A

Lipid A

non-immunogenic

14
Q

Shared among Enterobacteriaceae (heptose + KDO)

A

Core Polysaccharide

15
Q

Ag specific part of LPS

A

O somatic Ag

immunogenic

16
Q

LOS

A

shorter O chain

Same effect as LPS cause has LPS

17
Q

G- Outer membrane structures

A

Porins

Pili

18
Q

Form of G- bacteria after losing MOST of cell wall

A

Spheroplasts

can sometimes regen

19
Q

Endotoxin or Exotoxin?

G- only

A

endo

20
Q

Endotoxin or Exotoxin?

Part of cell wall

A

endo

21
Q

Endotoxin or Exotoxin?

LPS (not protein)

A

endo

22
Q

Endotoxin or Exotoxin?

Lethal dose 1 micro g

A

endo

23
Q

Endotoxin or Exotoxin?

Non enzymatic

A

endo

24
Q

Endotoxin or Exotoxin?

non-variable genetic traits

A

endo

25
Q

Endotoxin or Exotoxin?

G+ or G-

A

exo

26
Q

Endotoxin or Exotoxin?

Secreted

A

exo

27
Q

Endotoxin or Exotoxin?

Proteins

A

exo

28
Q

Endotoxin or Exotoxin?

Lethal dose ng or pg

A

exo

29
Q

Endotoxin or Exotoxin?

Enzymatic

A

exo

30
Q

Endotoxin or Exotoxin?

Variable genetic traits

A

exo

31
Q

Endotoxin or Exotoxin?

Enterotoxin

A

exo

32
Q

bacteria in blood but no symptoms

A

bacteremia

33
Q

bacteria in blood with symptoms

A

septicemia

34
Q

Super Ag list

A

TSST-1
Enterotoxin B/C
SPE A/B/C

35
Q

Pyrogenic and cause fever

A

IL-1beta and IL-6

36
Q

Capillary leak and cause hypotension

A

TNF-alpha

37
Q

Cause rash and T cell production

A

IL-2

38
Q

Macrophage activation and rash cause

A

IFN gamma

39
Q
G+ pathway to bacterial induced shock
Causative agent:
Receptor on Macrophage:
IL-1b:
TNF-a:
IFN-g +IL-2:
Lethal dose:
A
LTA
TLR 2/6
IL 1b
TNFa
no
1mg
40
Q
G- pathway to bacterial induced shock
Causative agent:
Receptor on Macrophage:
IL-1b:
TNF-a:
IFN-g +IL-2:
Lethal dose:
A
LPS
TLR-4
IL 1b
TNF a
no
1 micro g
41
Q
Super Ag  pathway to bacterial induced shock
Causative agent:
Receptor on Macrophage:
IL-1b:
TNF-a:
IFN-g +IL-2:
Lethal dose:
A
Super Ag
MHC-II/TCR cross link
IL-1b
TNF-a
IFNg + IL-2
0.1 micro g
42
Q

vBeta on TCR has ______ specificity

A

great