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Immunology > Lecture 3: Hematopoiesis > Flashcards

Lecture 3: Hematopoiesis Flashcards

1
Q

Hematopoiesis is regulated by what cytokines?

A

SCF

IL–1,3,6,7

CSF (G, GM, M)

EPO

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2
Q

B and T lymphocytes stem from

A

Common lymphoid progenitor

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3
Q

Multipotential hematopoietic stem cell can differentiate into ____ and _____

A

Common Myeloid Prog.

Common Lymphoid Prog.

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4
Q

These IL’s stilumate TCell differentiation

A

1,2,4,6,7

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5
Q

These factors stimulate differentiation into common myeloid progenitor

A

IL1,3,6

GM-CSF

SCF

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6
Q

These factors signal differentiation to common lymphoid progenitor

A

IL- 2,7,12

SDF-1

TNF-a. TGF-B2

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7
Q

Hematopoiesis occurs in _____ in adults

A

Bone marrow

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8
Q

Hematopoietic stem cells are ____ and ______

A

self-renewing

totipotent

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9
Q

HSC’s make ___, ____, and ______

A

Immune cells, Platelets, RBC’s

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10
Q

Dendritic Cells can originate from what cells?

A

Monocytes

(usually) MQ/DC Precursor cell

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11
Q

T cell contains ______ Antigen receptor

A

T cell

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12
Q

B cell contains ____ Antigen receptor

A

B cell

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13
Q

NK cells contain _____ Antigen receptor

A

they contain NO antigen-specific receptor

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14
Q

ILC cells contain _______ Antigen receptor

A

No antigen-specific receptor

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15
Q

Small Lymphocyte cell function

A

Production of Ab’s (B cells ) or helper and cytotoxic functions (T Cells)

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16
Q

Eosinphils kill ____ via ____

A

parasites, granule release

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17
Q

Neutrophil major surface marker

A

CD15

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18
Q

Neutrophils induced by

A

IL3

GM-CSF

G-CSF

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19
Q

Neutrophil antigen receptor:

A

None

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20
Q

Monocytes are precursors to

A

MQ’s and SOME DC’s

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21
Q

Antigen receptors on monocytes:

A

None

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22
Q

Major surface marker on Monocytes

A

CD14

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23
Q

These induce monocytes

A

IL3

GM-CSF

M-CSF

24
Q

Eosinophils kill what specifically

A

Ab-Coated parasites

25
Eosinophil antigen receptors:
None
26
Eosinophil effector machinery
Cytotoxic granules lipid mediators cytokines + chemokines
27
What induces eosinophil proliferation
T/Mast/Eosinophil-derived **_IL5_**
28
Eosinophils have ___ and ___ receptors
IgE + IgG
29
Mast cells two functions
Kill parasites Mediate Allergic response
30
Mast cell antigen receptor
none
31
Mast cell surface receptor
IgE receptor
32
Mast cells found in...
Connective tissues
33
Mast cells produce...
Cytokines IL 4, 5, 6, 13
34
\_\_\_\_\_\_ induces mast cells
Stem Cell Factor (SCF)
35
Basophil functions
* effector cells in allergic disorders * responds to parasites
36
Basophil receptor (sensor)
IgE receptor
37
Effector Machinery of Basophils
cytotoxic granules, lipid mediators, chemokines/cytokines
38
NK cell Antigen receptors
None
39
NK cell effector machinery is _____ and \_\_\_\_\_\_
perforins and granzymes
40
NK cell two receptor types and function
**Fc** and **MHC** Fc activate MHC inhibit
41
NK cell surface markers
CD16, CD56
42
T cells differentiate in \_\_\_\_\_\_
secondary lymphoid tissues
43
T cells antigen receptors
YES!
44
T cell functions:
Regulate **Humoral** and **CMIR**
45
T cell effector mechanisms (3)
Cytokines Cell Surface molecules Cytotoxic Granules
46
\_\_\_ is the defining Antigen for all T cells
CD3
47
Surface markers for T cells (3)
CD3, CD4, CD8
48
B cell surface markers
CD19+ CD20+
49
B cell Antigen receptors
YES! B cell Receptor (cell surface IG)
50
Function of B cells
Production of Immunoglobulins (GAME)
51
B cells are regulated by \_\_\_
T cells
52
B cells can also be activated...
Independently of T cells
53
Most circulating WBCs are
Neutrophils (40-75%)
54
Neutrophil enters _____ when there is \_\_\_\_\_\_
Tissue Inflammation
55
\_\_\_\_\_\_\_ are always entering the tissues
Monocytes
56
Recombinant ____ and ____ help boost _______ for neutropenia.
**GM-CSF** **G-CSF** help boost **Leukocyte production**
57
Recombinant ______ given for anemia patients?
EPO

Immunology (10 decks)

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