Lecture 3 Part 1: MUMPS, MEASLES, RUBELLA

Question 1

What virus family includes Morbillivirus, Paramyxovirus, and Pneumovirus?

Answer 1

Paramyxoviruses

Question 2

What is the main virus in the Morbillivirus genus?

Answer 2

Measles virus and has single serotype

Question 3

What are the main viruses in the Paramyxovirus genus?

Answer 3

Mumps virus and Parainfluenza viruses 1–4

Question 4

What viruses belong to the Pneumovirus genus?

Answer 4

RSV (Respiratory Syncytial Virus) and Metapneumovirus.

Question 5

A way to remember: Many People Play

Answer 5

Many People Play

Many = Morbillivirus → Measles

People = Paramyxovirus → Mumps + Parainfluenza 1–4

Play = Pneumovirus → RSV + Metapneumovirus

Question 6

What shape are Paramyxoviruses?

Answer 6

Pleomorphic (variable shape) with an envelope

Question 7

What type of nucleocapsid do Paramyxoviruses have?

Answer 7

Helical nucleocapsid

Question 8

What kind of genome do Paramyxoviruses have?

Answer 8

• Large, ssRNA(-) viruses
• Linear genome

Question 9

What special proteins do Paramyxoviruses carry with their nucleocapsid?

Answer 9

Nucleocapsid-associated proteins

Question 10

How are the three important Paramyxovirus genera distinguished?

Answer 10

By their viral attachment proteins

Question 11

What major diseases are caused by Paramyxoviruses?

Answer 11

measles and mumps

Question 12

How do Paramyxoviruses invade host cells?

Answer 12

By membrane fusion and released by budding

Question 13

What viral attachment protein is used by the Mumps virus?

Answer 13

HN (Hemagglutinin-Neuraminidase)

Question 14

What viral attachment protein is used by the Measles virus?

Answer 14

H (Hemagglutinin)

Question 15

Do Togaviruses have an envelope?

Answer 15

Yes, Togaviruses are enveloped viruses

Question 16

What shape is the Togavirus capsid?

Answer 16

Icosahedral

Question 17

What type of genome do Togaviruses have?

Answer 17

ss(+) RNA virus

Question 18

What are the two glycoprotein spikes found on Togaviruses?

Answer 18

E1 and E2

Question 19

Where do Togaviruses replicate inside the host cell?

Answer 19

in the cytoplasm

Question 20

What part of the body do Togaviruses first infect?

Answer 20

The upper respiratory tract

Question 21

How do Togaviruses spread through the body after infection?

Answer 21

They spread via viremia to lymphoid tissue, skin, and other organs

Question 22

What disease is caused by Togaviruses?

Answer 22

Rubella (German measles)

Question 23

Is Mumps virus highly contagious?

Answer 23

yes

Question 24

What type of infection does the Mumps virus cause?

Answer 24

lytic infection

Question 25

What gland does Mumps virus infect?

Answer 25

Parotid gland

Question 26

What symptom is caused by parotid gland infection?

Answer 26

painful swelling

Question 27

How does the Mumps virus spread in the body?

Answer 27

By viremia (through the blood).

Question 28

What serious complication occurs in 50% of Mumps cases?

Answer 28

CNS infection

Question 29

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