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HSF - Pharmacology > Lecture 30 - Autonomic pharmacology > Flashcards

Lecture 30 - Autonomic pharmacology Flashcards

(56 cards)

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1
Q

Muscle dystonia

A

Unwanted muscle contractions

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2
Q

Two neurotransmitters of major importance in the autonomic nervous system

A

Acetylcholine

Noradrenaline

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3
Q

Neurotransmitter at somatic nerve synapse

A

Acetylcholine

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4
Q

Neurotransmitter between pre- and post-ganglionic cells in parasympathetic

A

Acetylcholine

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5
Q

Neurotransmitter between post-ganglionic call and effector site in parasympathetic

A

Acetylcholine

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6
Q

Neurotransmitter between pre- and post-ganglionic cells in sympathetic

A

Acetylcholine

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7
Q

Neurotransmitter between post-ganglionic neuron and effector site in sympathetic

A

Norepinephrine

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8
Q

ACh nitoctinic receptor

A

Ligand-gated ion channel

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9
Q

ACh muscarinic receptor

A

GPCR

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10
Q

Adrenoceptor

A

GPCR

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11
Q

Muscarinic agonist in deadly nightshade

A

Atropine

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12
Q

Nicotinic receptor antagonist in curare

A

D-tubocurarine

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13
Q

ACh effect on muscarinic receptors

A

Decrease blood pressure

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14
Q

ACh effect on nicotinic receptors

A

Increase blood pressure

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15
Q

Alpha-adrenoceptor effect on blood pressure

A

Increase

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16
Q

Beta-adrenoceptor effect on heart rate

A

Increase

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17
Q

Receptors on post-ganglionic parasympathetic neuron

A

Nicotinic ACh receptor

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18
Q

Receptors on post-ganglionic sympathetic neuron

A

Nicotinic ACh receptor

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19
Q

Receptors on parasympathetic effector site

A

Muscarinic ACh receptor

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20
Q

Receptors on sympathetic effector site

A

alpha- and beta-adrenoceptors

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21
Q

Receptors on somatic effector site

A

Nicotinic ACh receptors

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22
Q

Vascular innervation

A

Sympathetic

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23
Q

Dopamine is a precursor of…

Study These Flashcards
A

Noradrenaline

24
Q

Reasons for manipulating CNS

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A

Controls somatic and autonomic nervous systems. Can have a wide effect.

25
Uses for Na+ blockers
Block action potentials Anti-epileptics Local anaesthetics
26
L-DOPA use
Dopamine precursor
27
Pseudoephedrine mode of action 1) 2) 3)
1) Displaces noradrenaline stored in vesicles 2) Displaced noradrenaline crosses synapse, stimulates post-synaptic cell. 3) Mimics sympathetic nervous system activation
28
Pseudoephedrine use
Nasal decongestant | Getting high
29
Moclobemide
MAOI | Increases noradrenaline 'leak' from sympathetic neurons
30
Botulinum toxin A mode of action
Blocks ACh release from presynaptic membrane Botox is proteolytic Degrades SNARE proteins
31
Uptake channels 1) 2)
1) Uptake 1 - High affinity, neuronal uptake | 2) Uptake 2 - Low affinity, extraneuronal uptake
32
Cocaine and tricyclic effects
Inhibit uptake 1 of noradrenaline
33
Neostigmine effects
Acetylcholineeseterase inhibitor
34
Neostigmine theraputic uses
Myasthenia gravis Increases effective half-life of ACh. Not a cure. Only treats symptoms
35
Beta-1 adrenoceptor agonists
Isoprenaline, dobutamine
36
Beta-2 adrenoceptor agonists
Salbutamol
37
Beta-1 and beta-2 adrenoceptor agonists
Isoprenaline
38
Beta-1 and beta-2 antagonists
Propranolol
39
Beta-1 adrenoceptor antagonist
Atenolol
40
Dobutamine use
Increases heart rate and force of contraction
41
Atenolol use
Reduces blood pressure
42
Salbutamol use
Asthma
43
Effects of beta-1 adrenoceptor stimulation
Increase heart rate, force of contraction
44
Effects of beta-2 adrenoceptor stimulation
Relaxation of bronchial smooth muscles
45
Alpha-1 adrenoceptor stimulation
Vasoconstriction
46
Phenylephrine uses
Nasal decongestant
47
Phenylephrine mode of action
alpha-1 adrenoceptor agonist
48
Prazosin use
Reduce hypertension
49
Prazosin mode of action
Alpha-1 adrenoceptor antagonist
50
Effects of stimulating muscarinic receptors
Smooth muscle contraction Decrease in heart rate Increased glandular secretion
51
Muscarinic receptor agonist
Pliocarpine
52
Muscarinic receptor antagonist
Atropine
53
Pilocarbine use
Glaucoma treatment
54
Atropine use: 1) 2) 3)
1) Dry up secretions and bronchiodilation for anaesthesia and surgery 2) Bronchiodilator for asthma 3) Coounteract anticholineesterase poisoning
55
Effects of nicotinic receptor stimulation: 1) 2)
1) Skeletal muscle contraction | 2) Ganglionic transmission
56
D-tubocurarine
Nicotinic receptor antagonist

HSF - Pharmacology (7 decks)

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