Flashcards in Lecture 31: Multifactorial Diseases Deck (10):
What does the thrombomodulin- thrombin complex do?
It cleaves protein C to activate it
What does Protein C do?
It inactivates Factors V and VIII
What is the thrombomodulin- thrombin complex?
It is a membrane bound protein that is found on the inner surface of endothelial cells that protrudes into the blood space. It binds thrombin.
What are two mutations that cause an increased genetic risk for DVT?
1. Factor V Leiden (G - A causes ARG to GLN substitution in protein which causes the protein C to be unable to destroy it)
2. Prothrombin (G - A in 3' UTR results in overly stable mRNA)
True/ False: Factor V Leiden and prothrombin are functional polymorphisms.
What is leptin?
Leptin is a hormone that is produced by fat cells (adipocyte) when fat stores increase.
What is the effect of leptin on the adipose tissues?
Increase triglyceride oxidation
increase uncoupling protein synthesis
Decrease fatty acid synthesis
What is the effect of leptin on skeletal muscle?
increase glucose uptake
increase glucose oxidation
What is the effect of leptin on the hypothalamus?
increase physical activity and energy expenditure