lecture 32 Flashcards
first step of FA synthesis
condensation of the growing chain with activated acetate
second step of FA synthesis
reduction of carbonyl to hydroxyl
third step of FA synthesis
dehydration of alcohol to trans-alkene
fourth step of FA synthesis
reduction of alkene to alkane
what does acetyl coa -> malonyl coa require
ATP
where is acetyl coa made
mitochondria
after lipolysis, fatty acids are transported by conjugation to
plasma albumin
where are fatty acids made
cytosol
where are fats degraded into fatty acids and glycerol
cytoplasm
where does beta oxidation of fatty acids occur
mitochondria
what happens to small (less than 12 carbons) FA
diffuse freely across mitochondrial membrane
larger fatty acids are transported via
acyl-carnitine/carnitine transporter
what replaces the S-CoA of Acetyl-coa when it enters the mitochondria
carnitine
what replaces the acyl-carnitine in the mitochondria
CoA-SH
first step of beta oxidation
activation of fatty acid by coenzyme A
enzyme for activation of FA
acyl coA synthetase
second step of beta oxidation
formation of double bond
product of second step of beta oxidation
FADH
third step of beta oxidation
addition of hydroxyl
what is added in third step of beta oxidation
water
fourth step of beta oxidation
oxidation to keto
byproduct of fourth step
NADH
last step of beta oxidation
cleavage to yield acetyl coa
what is propionyl coa turned into
succinyl coa
