Lecture 4-Schistosoma Flashcards
Phylum of Schistosoma
Platyhelmnithes
Class of Schistosoma
Digenea
Where are adult found?
blood vessels assoc. with intestines or bladder
intermediate host is a __?
snail
4 species that are the major causes of Schostosomiasis
- S. mansoni
- S. hematobulum
- S. intercalatum
- S. japonicum
What is the only effective drug against Schistosoma?
praziquantel
Which species is the most widespread?
S. mansoni
Where are the eggs released?
intestinal lumen –> feces
What affects the distribution of S. mansoni?
distribution of Biomphalaria (genus) snails
Which species of snails transmits the most S. mansoni?
B. pfeifferi
Where is S. mansoni usu. found in the globe?
Africa and parts of S. America and a little in N. America
Where is S. hematobuim found in the globe?
Africa
Where do adult worms of S. hematobium deposit eggs?
bladder of lumen
What snails does S. hematobium use?
Bulinus genus
What is the only species (that we studies) of Schistosoma that is zoonotic?
S. japonicum
Where is S. japonicum usu. found?
Asia
What snail species does S. japonicum use?
Oncomelania
Egg laying leads to mostly what response from immune system during chronic infection?
Th2
What is Th1 response for?
- cellular immunity
- macrophage, TNF, IFNgamma
What is Th2 response for?
- humoural immunity
- B-cells, eosinophil, mast cells
What innate immune cell is needed to switch from Th1 to Th2?
basophils