Lecture 5

Question 1

MOA - Cocaine/Methylphenidate

Answer 1

Cocaine and meth act as competitive reuptake inhibitors or reuptake blockers

Question 2

MOA - Amphetamine

Answer 2

Competitive substrate releasing agents because they displace monoamines from the presynaptic neuron

Question 3

MOA - Cathinones

Answer 3

Cathinone and Methcathinone act as preferential catecholamine inhibitors

Question 4

Psychostimulants Effects on Behaviour

Answer 4

Physiological
- increased heart rate, body temperature, and blood pressure, pupil dilation

Behavioural
- purposeful and purposeless behaviours increased

Subjective
- increased energy, alertness, sense of well-being, enthusiasm

Question 5

Harmful Effects

Answer 5

Liver damage, blurred vision, weight loss, paranoia, visual hallucinations, attention problems

Question 6

Treatment Approaches

Answer 6

Detoxification
- abstinence of drug

Behavioural Therapies
- cognitive, contingency, and community reinforcement

Pharmacotherapy
- modafinil stimulates dopamine, norepinephrine, and glutamate