Lecture 5 Resting Membrane Potenital

Question 1

Use Ionic Ohm’s Law

Answer 1

(gkEk +gNaENa+gCaECa+gClECl)/(gNa+gK+gCa+gCl)

Question 2

Explain the role of NaK Pump in relation to the RMP

Answer 2

The NaK is always running the pump and the pump only makes a small direct contribution to the membrane potential

So membrane potential is caused by the diffusion of K+ and Na+ down the conc grad through background channels

Question 3

Explain the outcome of variation in ion conc. in relation to pathophysiology

Increase ECF K

Hyperkalemic

Answer 3

depolarization

less negative

Question 4

Explain the outcome of variation in ion conc. in relation to pathophysiology

Increased ECF Na+

Hypernatremia

Answer 4

Depolarization less negative

Question 5

Explain the outcome of variation in ion conc. in relation to pathophysiology

Decreased ECF K

Hypokalemia

Answer 5

Hyperpolarization

More negative

Question 6

Explain the outcome of variation in ion conc. in relation to pathophysiology

Decrease Na+

Hyponatermic

Answer 6

Hyperpolarization

more negative

Question 7

RMP referes to diference that exist across the membrane of a _____ cell at steady state

Answer 7

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