Lecture 6

Question 1

Neuroendocrine tumors

Answer 1

•Require a multi-modality approach
• Pituitary adenomas
• Pancreatic Islet cell neoplasms
• Insulinomas
• GI neuroendocrine tumor (GI NET)
• Medullary cancer
• Pheochromocytomas
• Paragangliomas
• Neuroblastomas
• Small cell lung cancer
• Gastronomas & glucagonomas

Question 2

MEN 1

Answer 2

MEN1: Wermer’s
• Parathyroid
• Pituitary
• pancreas

Question 3

MEN 2A

Answer 3

MEN 2a: Sipple Syndrome
• Pheochromocytomas
• Parathyroid
• Medullar

Question 4

MEN 2B

Answer 4

MEN 2b
• Medullary
• Pheochromocytomas

Question 5

Describe the adrenal medulla

Answer 5

•10% of adrenal function
•Chromaffin cells - catecholamine’s
• Preganglionic neurons - postganglionic cells - hormone
secretion
• Epinephrine (adrenaline) 80%
• Relaxation of musculature
• GI tract, uterus, bronchi, urinary bladder
• Norepinephrine (noradrenaline) 20%
• Vasoconstriction & contraction
• Sphincters & uterus
• Dopamine

Question 6

Describe the adrenal cortex

Answer 6

•80-90% of adrenal function
•Produces and releases
• Aldosterone
• Cortisol, corticosterone, cortisone
• Hypothalamus CRH, pituitary ACTH
• Androgens/dehydroepiandrosterone
• Hypothalamus CRH, pituitary ACTH
•Loss of cortex
•  HR, CO, BP, blood flow, glucose and fatty acid levels
• Death