Lecture 6: Retina Flashcards
Name teh 3 main parts of a photoreceptor
Outer segment
Inner segment
Synaptic terminal
Describe inner segment
Contains cell nucleus and synaptic terminals
Describe outer segment
Contains stack of disks packed with light sensitive pigment molecules (photopigemnts)
Responsible for phototrasnduction
Define phototransduction
Process by which photoreceptor cells in retina convert light into electrical signals - neural acitvity = can be processed by brain
Define photopigemnts
1st step visual process= chemical process in photoreceptors
Ligth sensitive molecule in photoreceptors composed of opsin and chromophore
Define opsin
Protein sensitive to a specific wavelength of light
Protein component of photopigemnts, determines wavelength sensitivity of photoreceptor - enables colour and light detection, sensitivity to certain type of light
Define chromophore
Light absorbing molecule within photopigments
Mammals = 11 cis retinal - changes shape upon light absorption
Describe photopigemnt cycle - whole thing
Cycle of photoisomerization and regeneration = lets us see
11 cis retinal = receptive state —light—> photoisomerization = light changes shape of chromophore, isomerized = now all trans retinal - can no longer absorb light = bleached —> photopigment regeneration to get back to normal state —> 11 cis retinal
Define photoisomerization
Proces by which 11 cis retinal chromophore changes shape to all trans retinal when exposed to light = initiates phototransduction
Results in photoreceptor being bleached - renders it temporality unable to absorb more light
Define photopigemnt regeneration
Process fo converting all trans retinal back to 11 cis retinal form
Allows photoreceptors to recover from bleaching and resume light detection
Occurs in retinal pigment epithelium
How does light become transduced into neuronal activity
When number of bleached photopigments reaches a THRESHOLD = photoreceptor will change rate at which it releases nts to indicate it has received light = light transduced into neural activity
How many types of opsin does each photoreceptor
Rods = have rhodopsin (498 nm)
Cones = 3 types of photopsin = wavelength specific= basis of colour perception
Describe types of photopsin for cones
Short wave length specific cones = s-cones - perception of blue, 437nm
Medium = m-cones = green 533nm
Long = l-cones = red 564nm
What do some photoreceptor cells have
Melanopsin = can monitor ambient light levels = influence circadian rhythm
Unconscious perception of light cycle
Describe rods - when best
Sensitive to light intensities that are a million times smaller than the smallest intensity perceivable by cones
More sensitive
Fucntion better in low ligth conditions
Become overwhelmed = saturated in bright Environment
Describe cones - when best
Fucntion well in bright environment
Ineffective in low light conditions
Describe duplex retina idea
2 visual subsystems = bc differnce in light intensity between day and night = v large
Define photopic vision
Vision under well lit conditions
Primialry mediated by cones
Enable colour perception and high visual acuity
Define scotopic vision
Vision in low light conditions
Mediated by rods
Provide high sensitivy to light but no colour perception
Hard to see detail
Define dark adaptation
Process by which eyes adjust to low light conditions
Involves increased sensitivity of rods and shift from cone dominated to rod dominated vision
Can take up to 30mins
Name mechanism that allow us to see in dimly lit situations
Pupil dilation
Gain in sensitive of photoreceptors
Normalization through lateral inhibition
Describe pupil dilation - see in dimly lit
Allows entry of more light = see Bette
Fastest mechanism
Effects relatively limited
Describe gain in light sensitivity of photoreceptors - see in dimly lit
Dark environment associated with more regeneration than bleaching
Renders photoreceptors more receptive to light
Less receptors in bleached state in dark = more will be a viable to capture light
Maximum sensitivity of cones
5-8mins in dark = cones stop adapting
Limit to sensitivy of light cones can have