Lecture 6 - Seizures (also see pharm deck anticonvulsants) Flashcards Preview

ICM - Neurology > Lecture 6 - Seizures (also see pharm deck anticonvulsants) > Flashcards

Flashcards in Lecture 6 - Seizures (also see pharm deck anticonvulsants) Deck (6)
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1
Q

the most common type of seizure originates where? symptoms?

A

medial temporal lobe (hippocampus, amygdala);

confusion, memory loss, automatic behavior

2
Q

a ____ starts the seizure. this is followed by a period of ____

A

paroxysmal depolarization shift (PDS);

hyperpolarization

3
Q

PDS results primarily from activation of excitatory ___ mediated channels such as ___ and _____

A

glutamate;

AMPA, NMDA

4
Q

the hyperpolarization following the PDS is due to opening of ____ Dependent ____ channels, mainly.

A

calcium dependent K channels;

GABA also involved

5
Q

____ ____ is when a seizure spreads to adjacent cortical areas.

A

jacksonion march

6
Q

generalized seizures typically begin in subcortical areas such as the ____-. contributing to hyperexcitability are ____ ____ channels that open when a cell is depolarized

A

thalamus;

T-type calcium