Lecture 8(block 2) Mood Disorders And Suicide Managenent 1 Flashcards
What are depressive disorders?
Disorders that share in common low mood without abnormally high mood periods
Give examples of depressive disorders
- Major depressive disorder
- Persistent depressive disorder
- Premenstrual dysphoric disorder
- Disruptive Mood Dysregulation Disorder
What are the requirements of a diagnosis of Major Depressive disorder?
A person must experience atleast major depressive disorder
Person cannot have a history of mania or hypomania
Major depressive disorder is a ….
Unipolar depression
Describe a Major Depressive Episode
Atleast 2 weeks of 5 or more of the following, one or more must be depressed mood or anhedonia:
Affective- depressed mood, anhedonia
Neurovegetative- significant weight change, insomnia/hypersonia, loss of energy
Cognitive - psychomotor changes, feeling guilty/worthliness, decreased concentration, thoughts of death/ suicidal ideation
What are major depressive disorder specifiers?
Used to provide further description of the depressive episode
-A patient may have more than 1 specifier(or none)
What are Major depressive disorder specifier with melancholic features used for ?
Used for depressive episodes characterized by symptoms such as:
- Severe anhedonia, lack of mood reactivity, profound despondency and guilt
- Depression worse in the morning
- Early-morning awakenings
- Significant appetite loss
What is the purpose of for major depressive disorder specifier with atypical features?
Used for depressive episodes characterized by symptoms such as:
- Weight increase
- Sleep increase
- Mood reactivity
- Leaden paralysis
What is the purpose of Major depressive disorder specifier with psychotic features?
Used for depressive episodes characterized by hallucinations and/or delusions
- With mood-congruent psychotic features: the content of delusions/hallucinations is consistent with typical depressive themes
- With mood-incongruent psychotic features: the content of delusions/hallucinations
What is the purpose of Major depressive disorder specifier with catatonia?
Used for depressive episodes characterized by psychomotor symptoms such as:
- Mutism
- Immobility
- Waxy flexibility
- Stereotypes
- Other odd posturing
Describe Major depressive disorder specifier with Peri-Partum Onset
Used for depressive disorders in which the mood episodes begin during pregnancy or within 4 weeks post-delivery
Describe Major depressive disorder with Seasonal Pattern
Used for depressive disorders that show a consistent temporal relationship between time of the year and the mood episode
What is the general course of Major Depressive disorder?
- Usually starts up in in 20s and lasts 6-12 months in duration if left untreated
- Major Depressive Episodes are usually recurrent
- 5-10% of patients develop mania after several MDEs (diagnosis will then change)
Give the associated features of Major Depressive Disorder
-high psychiatric co-morbidity (e.g. substance dependence)
- Increased mortality and morbidity
- Approximately 15% commit suicide
- Presence of MDD worsens medical condition
Give the common findings neurobiological theory of depression
- A genetic predisposition for depression
- HPA axis overactivation resulting in chronic cortisol release and Immune system activation
- underactivity of monoamines( norepinephrine , serotonin, dopamine)
- Underactivity of prefrontal cortex (prefrontal cortex not inhibiting overactive HPA axis
What can be used to treat Major Depressive Disorder?
- Cognitive Behavioral therapy
- Antidepressant drugs
- Electroconvulsive therapy
- Vagus Nerve Stimulation
- rTMS
- Antidepressants
- Esketamine
- Phototherapy
How is phototherapy used for MDD treatment ?
- Exposure to bright artificial light
- Used for seasonal pattern of MDD( seasonal affective disorder)
How is Esketamine used for MDD treatment ?
A nasal spray
- Recently approved for treatment -resistant depression
- Rapid Antidepressant effects
- NMDA receptor blocker
How does Esketamine help in the treatment of MDD?
Works as a NMDA receptor blockade
How does ECT work in the treatment of MDD?
- Induction of seizures
- Potential fast-acting reversal of mood episode
How does VNS in MDD treatment?
Stimulates vagus nerve
How does rTMS work in MDD treatment ?
Stimulates prefrontal cortex
How does CBT work in treating MDD?
Correct biases in thinking (cognitive) and encourage behaviors associated with good mood( behavioral)
What MDD treatment options take 4-6 weeks for effect?
- CBT
- Antidepressants
- VNS
- rTMS