Lecture 8: Hormone Receptors Flashcards Preview

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Flashcards in Lecture 8: Hormone Receptors Deck (81)
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1

What are the 7 domains of a nuclear hormone receptor?

1. Hormone binding
2. DNA binding
3. Nuclear localization
4. Dimerization/Modulation/Phosphorylation domains
5. Transducing domain

2

What are the 6 domains of a membrane hormone receptor? Which ones are in the cell and which ones are out?

1. Hormone binding (out)
2. Transmembrane (within)
3. Dimerization (out)
4. Modulation (in)
5. Phosphorylation (in)
6. Transducing domain (in)

3

What are the 4 ways for a membrane hormone receptor to trigger a second messenger system?

1. Dimerization
2. Modulation
3. Phosphorylation domains
4. Enzymatic activity

4

What method is used by membrane receptors to induce a conformational change leading to transduction of response/second messenger cascade?

Dimerization

5

Which is inside the cell: N or C terminus of membrane hormone receptor?

Depends!

6

Where is the hormone-binding domain of nuclear hormone receptors? What is particular about it?

At the C-terminal
LARGE: ~250 AAs

7

What is the function of the nuclear localization domain of the nuclear hormone receptor?

Allows receptor to localize the nucleus of the cell

8

When does the nuclear hormone receptor enter the nucleus?

Could have always been there or upon binding to the hormone in the cytosol

9

What is the transducing domain of the nuclear hormone receptor?

Could be considered the entire hormone receptor

10

What is an agonist?

Molecule that binds to the hormone receptor and brings about a response

11

What is an antagonist?

Molecule that binds to the hormone receptor and inhibits the agonist responses

12

What is the role of the transducing domain of the membrane hormone receptor? What part of the receptor is it?

To induce second messengers
Cytoplasmic side of the receptor

13

What is the role of the transducing domain of the nuclear hormone receptor?

Activate transcription

14

Which bind better: agonists or antigonists?

Agonists usually

15

How can one determine if the binding domain of a hormone receptor binds the hormone reversibly?

Binding assay: scatchard plots

16

Which type of receptors can be glycosylated?

Membrane receptors

17

Which type of membrane receptors can have enzymatic activity??

Membrane receptors

18

What is an example of a partial/weak antagonist?

Ru486: works to inhibit progesterone receptor but partially inhibits the glucocorticoid receptor

19

What can an antagonist's properties depend on? Example?

The tissue it is in!
Eg: tamoxifen inhibits estradiol receptors well in breasts and poorly in bone

20

What does hGR stand for?

Glucocorticoid receptor

21

What does hMR stand for?

Mineralcorticoid receptor

22

What does hAR stand for?

Androgen receptor

23

What does hPR stand for?

Progesterone receptor

24

What does hERalpha and B stand for?

Alpha and beta estrogen receptors

25

What does hTR stand for?

Thyroid receptor

26

What are the 2 main types of hTRs?

Alpha 1 and beta 1

27

What does hRAR stand for?

Retinoic acid receptor

28

What are the 3 types of hRARs?

Alpha, beta, gamma

29

What does hRXR stand for?

Retinoic acid X receptor

30

What are the 3 types of hRXRs?

Alpha, beta, gamma