Lecture 8- Hypersensitivity

Question 1

Response in type 1 hypersensitivity

Answer 1

immediate

Question 2

Response in type 2 hypersensitivity

Answer 2

antibody-mediated

Question 3

Response in type 3 hypersensitivity

Answer 3

immune complex-mediated

Question 4

Response in type 4 hypersensitivity

Answer 4

T cell-mediated

Question 5

Pathologic immune mechanisms in type 1 hypersensitivity

Answer 5

IgE, Th2 cells

Question 6

Pathologic immune mechanisms in type 2 hypersensitivity

Answer 6

• IgM

- IgG against cell surface/extracellular matrix antigens

Question 7

Pathologic immune mechanisms in type 3 hypersensitivity

Answer 7

Immune complexes of circulating antigens and IgM or IgG

Question 8

Pathologic immune mechanisms in type 4 hypersensitivity

Answer 8

1. Th1 and Th17

2. Cytotoxic T cells

Question 9

Mechanisms of tissue injury/disease in type 1 hypersensitivity

Answer 9

Mast cells, eosinophils and their mediators

Question 10

Mechanisms of tissue injury/disease in type 2 hypersensitivity

Answer 10

• Opsonization and phagocytosis

- Complement and FcR-mediated immune recruitment

Question 11

Mechanisms of tissue injury/disease in type 3 hypersensitivity

Answer 11

Complement and FcR-mediated immune recruitment

Question 12

Mechanisms of tissue injury/disease in type 4 hypersensitivity

Answer 12

1. cytokine-mediated inflammation

2. direct target cell killing, cytokine-mediated inflammation

Question 13

Type 1 hypersensitivity is often referred to as…. and occurs within minutes after…. of allergen/antigen

Answer 13

• allergy, atopy, immediate

- reexposure

Question 14

… are synthesized via the lipoxygenase pathway and are a powerful inducer of bronchoconstriction and increased vascular permeability

Answer 14

Leukotrienes

Question 15

…. are the most effective long term control medication for asthma and is used as a daily preventative

Answer 15

Inhaled Corticosteroids

Question 16

Flovent, Qvar and Asmanex are examples of

Answer 16

inhaled corticosteroids

Question 17

Albuterol is a

Answer 17

inhaled long-acting beta2 agonist (“rescue medication”’)

Question 18

Inhaled long-acting beta2 agonists act on … to cause…

Answer 18

• beta-adrenergic receptors

- bronchodilation

Question 19

… medications help block the chain reaction that increases inflammation in your airways

Answer 19

Leukotriene inhibitors

Question 20

Singulair is an example of…

Answer 20

leukotriene inhibitors

Question 21

Most severe form of immediate hypersensitivity is

Answer 21

anaphylaxis

Question 22

Type 2 hypersensitivity is also called…

Answer 22

antibody dependent cytotoxicity

Question 23

3 diseases of type 2 hypersensitivity (antibody dependent cytotoxicity)

Answer 23

1. autoimmune hemolytic anemia
2. graves disease
3. myasthenia gravis

Question 24

The target antigen of graves disease

Answer 24

TSH receptor

Question 25

Graves disease is also called...

Answer 25

hyperthyroidism

Question 26

Mechanism of graves disease

Answer 26

antibody-mediated stimulation of TSH receptors

Question 27

Target antigen of myasthenia gravis

Answer 27

ACH receptor

Question 28

Mechanism of myasthenia gravis

Answer 28

antibody inhibits ACH binding to receptor

Question 29

Treatment of myasthenia gravis

Answer 29

cholinesterase inhibtors and corticosteroids

Question 30

Treatment od graves disease

Answer 30

radioactive iodine, anti-thyroid drugs, thyroid removal

Question 31

Type 3 hypersensitivity is.... mediated

Answer 31

immune complex-mediated

Question 32

4 causes of serum sickness

Answer 32

1. antivenome 2. anti-lymphocyte globulin 3. antibiotics 4. streptokinase

Question 33

Which hypersensitivity results in Ag-Ab complexes that clump near blood vessels attracting an acute inflammatory rxn

Answer 33

3