Lecture 8- Hypersensitivity Flashcards Preview

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Flashcards in Lecture 8- Hypersensitivity Deck (33)
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1
Q

Response in type 1 hypersensitivity

A

immediate

2
Q

Response in type 2 hypersensitivity

A

antibody-mediated

3
Q

Response in type 3 hypersensitivity

A

immune complex-mediated

4
Q

Response in type 4 hypersensitivity

A

T cell-mediated

5
Q

Pathologic immune mechanisms in type 1 hypersensitivity

A

IgE, Th2 cells

6
Q

Pathologic immune mechanisms in type 2 hypersensitivity

A
  • IgM

- IgG against cell surface/extracellular matrix antigens

7
Q

Pathologic immune mechanisms in type 3 hypersensitivity

A

Immune complexes of circulating antigens and IgM or IgG

8
Q

Pathologic immune mechanisms in type 4 hypersensitivity

A
  1. Th1 and Th17

2. Cytotoxic T cells

9
Q

Mechanisms of tissue injury/disease in type 1 hypersensitivity

A

Mast cells, eosinophils and their mediators

10
Q

Mechanisms of tissue injury/disease in type 2 hypersensitivity

A
  • Opsonization and phagocytosis

- Complement and FcR-mediated immune recruitment

11
Q

Mechanisms of tissue injury/disease in type 3 hypersensitivity

A

Complement and FcR-mediated immune recruitment

12
Q

Mechanisms of tissue injury/disease in type 4 hypersensitivity

A
  1. cytokine-mediated inflammation

2. direct target cell killing, cytokine-mediated inflammation

13
Q

Type 1 hypersensitivity is often referred to as…. and occurs within minutes after…. of allergen/antigen

A
  • allergy, atopy, immediate

- reexposure

14
Q

… are synthesized via the lipoxygenase pathway and are a powerful inducer of bronchoconstriction and increased vascular permeability

A

Leukotrienes

15
Q

…. are the most effective long term control medication for asthma and is used as a daily preventative

A

Inhaled Corticosteroids

16
Q

Flovent, Qvar and Asmanex are examples of

A

inhaled corticosteroids

17
Q

Albuterol is a

A

inhaled long-acting beta2 agonist (“rescue medication”’)

18
Q

Inhaled long-acting beta2 agonists act on … to cause…

A
  • beta-adrenergic receptors

- bronchodilation

19
Q

… medications help block the chain reaction that increases inflammation in your airways

A

Leukotriene inhibitors

20
Q

Singulair is an example of…

A

leukotriene inhibitors

21
Q

Most severe form of immediate hypersensitivity is

A

anaphylaxis

22
Q

Type 2 hypersensitivity is also called…

A

antibody dependent cytotoxicity

23
Q

3 diseases of type 2 hypersensitivity (antibody dependent cytotoxicity)

A
  1. autoimmune hemolytic anemia
  2. graves disease
  3. myasthenia gravis
24
Q

The target antigen of graves disease

A

TSH receptor

25
Q

Graves disease is also called…

A

hyperthyroidism

26
Q

Mechanism of graves disease

A

antibody-mediated stimulation of TSH receptors

27
Q

Target antigen of myasthenia gravis

A

ACH receptor

28
Q

Mechanism of myasthenia gravis

A

antibody inhibits ACH binding to receptor

29
Q

Treatment of myasthenia gravis

A

cholinesterase inhibtors and corticosteroids

30
Q

Treatment od graves disease

A

radioactive iodine, anti-thyroid drugs, thyroid removal

31
Q

Type 3 hypersensitivity is…. mediated

A

immune complex-mediated

32
Q

4 causes of serum sickness

A
  1. antivenome
  2. anti-lymphocyte globulin
  3. antibiotics
  4. streptokinase
33
Q

Which hypersensitivity results in Ag-Ab complexes that clump near blood vessels attracting an acute inflammatory rxn

A

3