Left to know

Question 1

Sumatriptan (GPCR)

Answer 1

migranes

Question 2

cetirizine (GPCR)

Answer 2

antihistamine

Question 3

salbutamol (GPCR)

Answer 3

asthma

Question 4

atenolol (GPCR)

Answer 4

hypertension

Question 5

Asthma treatment

Answer 5

beta-agonists (salbutamol)
stimulate beta-2 adrenergic receptors that result in bronchodilation

Question 6

GPCR antagonists

Answer 6

block overactive GPCRs for example from choleraetoxin (adds ADP ribose to G protein keeping it in an active state)

Question 7

Malaria symptoms

Answer 7

Fever, vomiting, nausea, muscle pain, dry cough

Question 8

Malaria species

Answer 8

Vivax, ovale, falciparum, malariae

Question 9

Sulfonomides

Answer 9

Inhibit dihydropteroate synthase (which catalises formation of dihydropteroate)

Question 10

Proguanil and pyrimethamine

Answer 10

Ihibits dihydrofolate reductate (catalises formation of tetrahydrofolic acid from dihydrofolate)

Question 11

Quinine and chloriquine

Answer 11

Inhibits haem polymerase (formation of hemozoin)

Question 12

Barbiturates

Answer 12

mass inhibition
used as anasthetics and epilepsy treatment
dangers: stop breathing

long term: tolerance, withdrawal symptoms

Question 13

benzodizepines

Answer 13

Epilepsy and anixiety (diazepam)
potentiate effect og GABA

long term: tolerance, withdrawal symptoms

Question 14

Ethanol biphasic (alcohol)

Answer 14

low dose: disinhibition (potentiates effect of GABA)
high dose: global inhibition (sedation, impaired function)

also stimulates dopamine release (euphoria)

Question 15

NMDA receptor antagonist

Answer 15

Ketamine

Question 16

Structure of local anasthetics

Answer 16

aromatic group-
ester/amide-
basic side chain (amine)

Question 17

Drugs affecting neurotransmissiom

Answer 17

Haemocholinim (choline uptake inhibitor)
Triethylcholine (false transmitter)

Question 18

Tyrosine kinase receptors

Answer 18

one agonist binds two TK
autophosphorylate eachother (SH2 protein is phosphorylated)

Question 19

Conditions for schild to apply

Answer 19

B is a true competetive antagonist

A and B binding is mutually exclusive

Kb is constant

Same occupancy of A always gives the same response

system is at equilibrium

Question 20

Chemical antagonism

Answer 20

antagonist binds to agonist not receptor (Heparin)

Question 21

Functional antagonism

Answer 21

Antagonist is an agonist that produces the opposite effect (beta-adrenergic receptors to reduce asthma)

Question 22

Pharmakokinetic antagonism

Answer 22

works to reduce the concentration of agonist (warfarin)

Question 23

Indirect antagonism

Answer 23

works at a secondary downstream site (verapmil)

Question 24

Vancomycin

Answer 24

Inhibition of Transglycosilation of peptidoglycan

Question 25

Erythromycin

Answer 25

(50s)Inhibition of translocation

Question 26

Tetracycline

Answer 26

(50s)disruption of tRNA-mRNA interactions

Question 27

Streptomycin

Answer 27

(30s)Causes mkisreadings of RNA

Question 28

Chloramphenicol

Answer 28

(50s) inhibits transpeptidation

Question 29

Tuberculosis treatment

Answer 29

Isoniazide (inhibits mycolic acid necessary for formation of cell wall) Rifampin (RNA polymerase inhibitor) Pyrazianamide