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Flashcards in Legionella Deck (20):
1

Legionella pneumophilia is a gram _____ _____

Gram negative bacilli

2

What virulence factor of L. pneumophilia induces a macrophage to take it up by coiling phagocytosis?

Mip (Macrophage infectivity promoter)

3

What two virulence factors of L. pneumophilia disturb acidification of the phagosome, prevent lysosomal fusion and take over organelle trafficking to provide nutrients, ultimately making a nice home for the organism out of a phagosome?

  • Icm (intracellular multiplication
  • Dot (defect in organelle trafficking)

4

L. pneumophilia produces _____ to help it spread through tissues.

Metalloproteases

5

L. pneumophilia produce _____ and _____ to help it get out of the phagosome when ready

Hemolysins and phospholipases

6

L. pneumophilia is ubiquitous in what kind of environments?

Fresh water

7

L. pneumophilia is notorious for living in what household appliance?

Air conditioning cooling towers

8

How is L. pneumophilia acquired?

Via aerosolization and subsequent inhalation

9

Legionella, once inhaled, is covered in C3b then, enter macrophages through _____ or _____ phagocytosis

  • Coiling phagocytosis
    • via CR1 & CR3
  • Conventional phagocytosis
    • via Fc

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10

What two groups are at risk for L. pneumophilia infection?

  • Pts. with decreased cellular imunity
  • Pts. with compromised pulmonary function

11

The initial symptoms of Legionnaire's disease that occur

2-10 days after exposure are _____.  They can progress to a _____ pneumonia.

  • Flu like
    • Fever, chills, headache, nonproductive cough
  • Can progress to a necrotizing pneumonia

12

The necrotizing pneumonia of advanced Legionnaire's disease deomonstrates _____ consolidation, _____, and a "_____" appearance

  • Multilobar consolidation
  • Microabscesses
  • "Moth eaten" appearance on xray

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13

_____ is a milder form of Legionnaires that presents with similar flu-like symptoms, but WITHOUT _____

Pontiac Fever presents similarly to Legionnaire's, but WITHOUT PNEUMONIA

14

T/F Pontiac Fever requires antibiotics

FALSE

There is a spontaneous cure about 2-5 days after illness

15

Antigen for the L. pneumophilia serogroup 1 can be found in _____

Urine

16

What kind of medium does L. pneumophilia grow on? 

BCYE (Buffered charcoal yeast extract)

 

Look how pretty: 

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17

Assessing the _____ for presence of L. pneumophilia is not a good option.

  • Sputum
    • No productive cough
    • Check bronchial lavage, lung biopsy, blood (if septic), pleural fluid (if effusion present)

18

What stains are used to diagnose L. pneumophilia infetion?

  • Silver stain
  • Immunofluorescence stain

19

What treatment options are available for Legionnaire's Disease?

  • Macrolides
    • Azithromycin
    • Clarithromycin
  • Fluoroquinolones

20