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Flashcards in Leprosy Deck (27)
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1

leprosy is a __________disease affecting _____ and _____ tissues 

chronic granulomatous disease affecting peripheral and superficial tissues

2

where does leprosy mostly infect?

nasal mucosa

3

how is M. leprae different from M. tuberculosis?

M. leprae cannot be grown on agar media or in cell culture

4

hosts of M. leprae?

amardillos and humans

5

what are the two major forms of leprosy?

tuberculoid and lepromatous

6

how is M. leprae transmitted?

via small droplets from nasal secretions of lepromatous leprosy pts

7

infectivity of leprosy? incubation time?

infectivity is low, incubation period is estimated to be 2-7 years

8

what does contraction of the disease require

prolonged contact with an infected person

9

where is leprosy common in the world?

India and Brazil

10

describe M. leprae

an acid fast bacillus that likes cool temperatures.obligate intracellular parasite of primarily of macrophages and Schwann cells --> can also invade peripheral neurons  

11

which type of leprosy lacks Th1 mediators?

lepromatous

12

disease of tuberculoid leprosy?

single skin lesions on the face, limbs, and buttocks

13

number of organisms present in tuberculoid leprosy lesions? is the patient contagious?

low #, pt. not contagious

14

prognosis of tuberculoid leprosy

tuberculoid lesions can heal spontaneously and prognosis is good

15

how does lepromatous leprosy progress? what are the first signs of disease?

progressive disease with the first signs being edema, and rhinitis

16

where are the lesions of lepromatous leprosy? think: FBL

extensive on face, buttocks, and limbs

17

where on body can you observe acid-fast staining bacilli from scrapings

inner ear infection of lepromatous leprosy

18

what type of damage can lepromatous leprosy cause?

SEVERE damage! perforation of the nasal septum and collapse of the nose due to cartilage loss, loss of fingers to neurotrophic atrophy, atrophy of testticles

19

how does lepromatous leprosy spread?

reticuloendothelial system

20

how is leprosy diagnosed? why?

clinically b/c organisms cannot be grown in culture

21

how is the diagnsosis confirmed?

skin biopsies and the detection of acid-fast staining bacilli

22

is antibiotic resistance a problem? what is done about it?

yes; multidrug therapy

23

which drug combo can cure tuberculoid leprosy?

sulfone + rifampin = cure of tuberculoid leprosy w/6 mos. treatment

24

tx for lepromatous form

clofazimine is added and tx lasts at least 2 years

25

for the lepromaotus form, what can be given as prophylaxis to kids in close contact with lepromatous pts?

sulfones

26

what is the key to prevention?

early diagnosis and treatment

27

 M. leprae is an obligate intracellular parasite of primarily of __________ and ____________ --> can also invade peripheral neurons  

 M. leprae is an obligate intracellular parasite of primarily of macrophages and Schwann cells --> can also invade peripheral neurons