Leprosy

Question 1

Chronic infection of the nerves with skin manifestations

Answer 1

Leprosy

Question 2

other name for Leprosy

Answer 2

Hansen’s disease

Question 3

Criteria for leprosy

Answer 3

1. 1/3 or 2/3 criteria
2. retrieved defaulters with signs of active disease
3. relapsed patients who previously completed a full course treatment

Question 4

Diagnoses of leprosy

Answer 4

1. hypopigmented or redish skin lesion with loss of sensation
2. involvement of peripheral nerves
3. skin smear positive for acid fast bacilli

Question 5

incubation period for M. leprae

Answer 5

5 years ( 6 months to 20 yrs)

Question 6

Mjor route of M. leprae

Answer 6

Respiratory

Question 7

Preferred areas of growth of M. leprae

Answer 7

Skin
Superficial peripheral nerves
Anterior chamber of eyes
Testes

Question 8

Single or few, asymmetrical, well-defined hypopigmentation, erythematous or copper-colored patches with raised borders
mild form, no satellite lesions

Answer 8

Tuberculoid Leprosy

Question 9

Few, asymmetrical, well- demarcated, dry plaques, may be annular, may be scaly, clearly defined outer borders

Answer 9

Borderline Tuberculoid Leprosy

Question 10

more numerous lesions than tuberculoid ones > 3 and <10 lesions
asymmetrical, less well demarcated, shiny plaques

Answer 10

Mid borderline Leprosy

Question 11

numerous (>5), smaller roughly symmetrical, shiny macules, papules, nodules and plaques with sloping edges
annular punched out lesions

Answer 11

Borderline Lepromatous Leprosy

Question 12

Very numerous, symmetrically distributed, erythematous or copper-colored shiny macules, papules and nodules
(+) infiltration in the skin
(+) lepra bonita

Answer 12

Lepromatous leprosy

Question 13

Multibacillary

Answer 13

> 5 skin lesions
+ AFB in skin smear
1 nerve trunk involved

Question 14

Paucibacillary

Answer 14

< 5 skin lesions
No AFB in skin smear
0-1 nerve trunk involved

Question 15

Component of MDT

Answer 15

Rifampicin
Clofazimine
Dapsone

Question 16

Patient becomes non infectious in ______

Answer 16

1 month

Question 17

Treatment of paucibacillary leprosy

Answer 17

Rifampicin 600 mg once a month

Dapsone 100 mg for 6 months

Question 18

Treatment of Multibacillary leprosy

Answer 18

Rifampicin 600 mg and Clofazimine 300 mg once a month

Dapsone 100 mg and Clofazimine 50 mg daily for 12 months or until skin smears show no more bacilli

Question 19

Side effects of MDT

Answer 19

Rifampicin ( reddish urine)
Clofazimine ( dark brown skin)
Dapsone ( hemolytic anemia)