Leukemia

Question 1

CML is Common in__________

Answer 1

Old age

Question 2

Difference between leukemoid reaction and CML

Answer 2

Leukemoid takes leukocyte alkaline phosphatase (LAP)

Question 3

Philadelphia chromosome( 9:22 translocation is associated with)

Answer 3

CML

Question 4

Mgt of CML

Answer 4

Thyrosine kinase inhibitor

Question 5

CLL is common in____________

Answer 5

Adult and old age

Question 6

Smudge cells are seen in peripheral morphology in ____________

Answer 6

CLL
And 30% blast cells in bone marrow biopsy
Mgt IV immunoglobulin

Question 7

Rare type of B cell neoplasm

Answer 7

Hairy cell Leukemia

Question 8

Hairy like projection in peripheral smear and dry bone marrow biopsy shows ____________

Answer 8

Hairy cell leukemia

Question 9

Blast referee to as

Answer 9

Defective cells which account for more than 20%

Question 10

Hepatosplenomegally and lymphadenopathy is common in

Answer 10

ALL

Question 11

Gum swelling due to monocyte infiltration is caused by

Answer 11

AML

Question 12

Auer rod is seen in

Answer 12

AML(crystalized aggregates if myeloperoxidase is enzymes)

Question 13

TDT is positive in

Answer 13

ALL

Question 14

Trans retinoic acid

Answer 14

Helps the blast to mature in to neutrophils in case of ALL

Question 15

AML

Answer 15

Myeloblast
Erythroblast
Leukocytes
Granulocyte

Question 16

Thyrosine kinase inhibitor have a less effect for

Answer 16

CLL

Question 17

Blood smear of CML shows

Answer 17

Increased granules

Question 18

Hodgkin’s lymphoma risk factors

Answer 18

TB
HSV
EBV
Phenytoin

Question 19

B ssx of lymphoma

Answer 19

Fever
Night sweat
Weight loss
Others
Lymphadenopathy
Splenomegaly
Bone lesion

Question 20

Reed sternberg cells are seen in

Answer 20

Hodgkins lymphoma (large binucleat cells in biopsy)

Question 21

Remission of Hodgkin’s lymphoma is around?70-80 %

Answer 21

80

Question 22

Lymph tissues are

Answer 22

Spleen
Bone marrow
Lymph nodes

Question 23

Indulent lymphoma have

Answer 23

Long survival rate but not curable

Question 24

Richter syndrome

Answer 24

Transformation of NH lymphoma to SLL/CLL

Question 25

Indolent lymphoma

Answer 25

Follicular SLL /CLL Cutaneous T cell Marginal zone

Question 26

Aggressive NH lymphoma are

Answer 26

Burkitt Mantle cell Follicular Peripheral T cell Adult T cell Anaplastic large cell AIDS associated Lymphoblastic leukemia

Question 27

Risk factors for NH lymphoma

Answer 27

Hep B or c EBV

Question 28

Cd 20 is positive for

Answer 28

B cell non Hodgkin’s lumphoma

Question 29

CD 15 and 30 is positive in

Answer 29

Hodgkin’s lymphoma

Question 30

DLBCL occurs

Answer 30

Spontaneous

Question 31

Excisional biopsy is seen in

Answer 31

Malignant lymphoma

Question 32

Motle cell lymphoma

Answer 32

Have GI ssx

Question 33

Weldenstorm myceoglobulinemia

Answer 33

Abnormal igm production Neuropathy

Question 34

Hodgkin’s lymphoma causes hepercalcemia in what mechanism

Answer 34

Increase in alpha 1 hydroxylase activity

Question 35

Good prognosis for Hodgkin’s lymphoma

Answer 35

Young age Lymphocytosis

Question 36

Poor prognosis for Hodgkin’s lymphoma

Answer 36

High ESR 3 or more lymph node involved Bulky disease

Question 37

Hairy cell leukemia

Answer 37

Tartrate resistant acid phosphatase activity