Leukemia

Question 1

Bone marrow aspiration done using which needle?

Answer 1

Salah’s- side screw
Klima
Jamshidi- used for BM biopsy and aspiration

Question 2

Indication for BM bx

Answer 2

Aplastic anemia
Myelofibrosis
AML m7 which causes myelofibrosis
Hairy cell leukemia which causes myelofibrosis
Space occupying lesions in MB - granuloma, mets

Question 3

Hypersegmented neutrophils found in?

Answer 3

Vit B12 deficiency

Question 4

Hyposegmented neutrophil also called as and is seen where?

Answer 4

Pelger huet cell
Myelodyplastic syndrome

Question 5

What are dohle bodies?

Answer 5

Patches of dilated endoplasmic reticulum and seen in infections

Question 6

Diagnostic criteria of acute leukemia

Answer 6

WHO:
>20% blast cells in ps/bm
<20% blast cells with t(8;21), t(15;17), inv 16
FAB>30% blasts in bm

Question 7

What are fagot cells

Answer 7

Clusters of auer rods
Auer rodes: made up of lysosomes

Question 8

MC leukemia in children

Answer 8

ALL

Question 9

Cytogenetics of ALL

Answer 9

B-ALL: PAX5, E2A, RUNX1,EBF.
TALL: NOTCH1

Question 10

Which type of ALL is most common

Answer 10

FAB classification- L1 ( Pre B cell ALL)
WHO classical - B-ALL

Question 11

Which has the worst prognosis

Answer 11

FAB classification- L3
WHO classification- T-ALL

Question 12

Prognostic factors in ALL

Answer 12

Good: hyperdiploiy,
Bad: hypodiploidy

Question 13

What is the stain for ALL

Answer 13

PAS-DOT/block positivity

Question 14

CD markers of ALL

Answer 14

B-cell: CD 19 20 22 PAX5
Tcell: CD1 2 3 5 7.
Both: TdT +

Question 15

Treatment of ALL

Answer 15

Vincristine, l-Asperginase, Prednisolone, Doxorubicin— VAPD Regimen

Question 16

What kind of cells are seen in ALL

Answer 16

Hand mirror cells

Question 17

Age presentation of AML

Answer 17

Middle age

Question 18

Cytogenetics of AML

Answer 18

M2 (most common):t(8,21)
M3: best prog, t(15;17), faggot cells+, DIC
M4: inv 16

Question 19

Which AML is PAS Diffusely positive.

Answer 19

AML7: least common

Question 20

What is Di Guglielmo disease

Answer 20

AML M6

Question 21

Which AML leads to dry tap on bma?

Answer 21

AML M7- myelofibrosis

Question 22

Age presentation of CML

Answer 22

Middle age

Question 23

Cytogenetics of CML

Answer 23

T(9;22)- Philadelphia chr

Question 24

What is chloroma

Answer 24

Aka- myeloblastoma
Commonly seen in aml ie -aml m2
MC sute: orbit
Mpo +
Arbiskov cells monocytes in chloroma

Question 25

C/F on aml

Answer 25

Anemia Infections Bledding Gum hyoertrophy Chloroma DIC

Question 26

Massive splenomegaly seen in

Answer 26

Kala azar Malaria CML (MDS) Polycythemia vera Myelofibrosis Gauchers diseases

Question 27

Convent girl appearance on pS seen in

Answer 27

CLL

Question 28

College school girl appearance seen in

Answer 28

CML

Question 29

What are pseudo gaucher cells

Answer 29

Seen in BM in CML Wrinkled cytoplasm

Question 30

BM findings of CML

Answer 30

Sea blue histiocytes Pseudo guacher cells

Question 31

Treatment of CML

Answer 31

Imatinib tesylate

Question 32

NAP score, define

Answer 32

Neutrophil alkaline phosphatase To determine neutrophil activity Low in CML, PNH High in leukemoid reaction, pregnancy, stress, other MPS

Question 33

Age presentation of CLL

Answer 33

Elderly

Question 34

Cytogenetics of CLL

Answer 34

Trisomy 12, del chr 13q and 17p

Question 35

Where is aiha seen in leukemia

Answer 35

CLL

Question 36

Basket/ parachute cells seen in

Answer 36

CLL

Question 37

What is pathognomic in LN bx in CLL

Answer 37

Proliferative

Question 38

CD markers of CLL

Answer 38

CD 5 23 200