Leukemia/Lymphoma tumor markers

Question 1

Tdt+, Calla antigen:

Cancer associated?

Answer 1

ALL

usually kids

Question 2

t(12;21) indicates a good prognosis in what cancer/age group?

Answer 2

B-cell ALL

Children 2-10 (Most common cancer of children)

Question 3

CD20+, CD5+ and hypogammaglobulinemia. Cancer and age group?

Answer 3

CLL/SLL

Adults >60

Question 4

Smudge cells are seen in what cancer?

Answer 4

CLL/SLL

Question 5

t(14;18) with BCL2 positivity- What cancer?

Answer 5

Fo-llicular Lymphoma (Fo-teen 18)

Question 6

c-MYC oncogene translocation on chromosome 8 is associated with what cancer and age group?

Answer 6

Burkitt Lymphoma

Young adults

Question 7

t(11;14) of cyclin D1 and heavy chain Ig. What cancer?

Answer 7

Mantle cell lymphoma (NHL)

Question 8

Starry sky appearance on blood smear with tingible body macrophages. Cancer associated?

Answer 8

Burkitt Lymphoma

Question 9

Cerebriform nuclei, cutaneous symptoms, atypical CD4+ cells. Cancer associated?

Answer 9

Mycosis fungoides

Question 10

M spike with increased light chains in urine- Associated cancer?

Answer 10

Multiple myeloma

Question 11

Massive splenomegaly, pancytopenia, and dry bone marrow tap. Cancer associated?

Answer 11

Hairy Cell Leukemia

Question 12

t(15;17) and high incidence of DIC. Cancer associated?

Answer 12

M3 AML- Acute Promyelocytic Leukemia (APL)

Question 13

inv(16), myeloperoxidase and nonspecific esterase+. Cancer associated?

Answer 13

M4 AML- Acute Myelomonocytic leukemia

Question 14

What is Richter syndrome?

Answer 14

Transformation of CLL/SLL–> DLBCL

Question 15

BCR-ABL fusion gene from t(9;22)- Associated with what cancer?

Answer 15

CML

Question 16

Presentation of EBV+ Burkitt’s Lymphoma?

Answer 16

Presents in mandible of young adults with a predilection for solid organs

Question 17

MYD88 gene mutation with high levels of IgM. Associated cancer and treatment?

Answer 17

Lymphoplasmacytic Lymphoma–> causes Waldenstrom macroglobulinemia, which is treated with plasmapheresis

Question 18

Reed-Sternberg cells are characteristic of what cancer?

Answer 18

Hodgkin’s Lymphoma

Question 19

HTLV-1 is associated with what cancer? What cells are cancerous?

Answer 19

Adult T-Cell Leukemia/Lymphoma (ATLL)

CD4+ T-helper cells

Question 20

Russell bodies, Mott cells, and Rouleax formation is associated with what cancer?

Answer 20

Multiple myeloma

Question 21

What are the myeloproliferative disorders?

Answer 21

Polycythemia Vera
Essential thrombocytosis
Primary myelofibrosis

Question 22

TRAP stain+, tx with Cladribine:

Answer 22

Hairy Cell Leukemia

Question 23

CLL, lymphoplasmacytic lymphoma, follicular lymphoma, EBV, marginal zone lymphoma can all transform into

Answer 23

DLBCL

Question 24

What hyperviscosity syndrome presents with an M spike?

Answer 24

Waldenstorm macroglobulinemia

Question 25

Multiple myeloma: 4 main findings?

Answer 25

``` CRAB hyperCalcemia Renal involvement Anemia Bone lytic lesions ```

Question 26

Pseudo-Pelger-Huet anomaly (neutrophils with bilobed nuclei) are associated with what?

Answer 26

Myeldysplastic syndromes

Question 27

ALK rearrangements indicate a good prognosis in what cancer?

Answer 27

Anaplastic Large Cell Lymphoma (T-Cell)

Question 28

What cancer usually has a STAT3 mutation and cells with abundant blue cytoplasm and azurophilic granules?

Answer 28

Large granular lymphocytic leukemia | Peripheral NK/T cell neoplasm

Question 29

An absolute lymphocyte count >5000, found on routine physical indicates what?

Answer 29

CLL