Leukocyte disorders Flashcards
Child with paroxysmal cough and lymphocytosis
Pertussis
Child with atypical lymphocytes and splenomegaly
Mono
Child with allergies, eczema, and low platelets
WAS
Weeks old infant with severely low ANC
Isoimmune Neonatal Neutropenia
Child with mouth ulcers and waxing and waning symptoms
Cyclic neutropenia - elastase gene, autosomal dominant
Infant with skin lesions, ear infections, and low ANC
Sevre congenital neutropenia - treat with GCSF and antibiotics
Patient with growth failure and fat malabsorption
Shwachmann Diamond
Child with low ANC after viral infection
Benign neutropenia
Child with ALL gets a fever and low ANC
Fever and neutropenia syndrome
Patient with pancytopenia and symptoms consistent with a syndrome
HLH - widespread macrophage activation
Patient with bone marrow hypoplasia, increased MCV, and skeletal anomalies
Fanconi Anemia (inherited aplastic anemia; DNA repair defect)
Gray haired / light skinned patient
Chediak Higashi
Child with high WBC count, prolonged umbilical separation, and recurrent infections
Leukocyte Adhesion Deficiency - qualitative defect
Child with lymphadenitis, skin lesions, bladder problems
CGD - chronic granulomatous disease (can’t generate oxidative burst)
Child with recurrent sinopulmonary infections without IgA in serum
Selective IgA deficiency - autosomal dominant - high risk of autoimmune diseases
