Leukocyte Disorders part 1 & 2

Question 1

Quantitative term in terms of decrease RBC, WBC, and platelets?

Answer 1

Pancytopenia

Question 2

Absolute count of neutrophilia?

Answer 2

> 7.0 - 8.0 x 10^9/L

Question 3

Treatment for neutrophilia?

Answer 3

Corticosteroids and lithium

Question 4

Usually transient or short-term increase of WBC?

Answer 4

Physiologic neutropenia

Question 5

Most common type of leukopenia?

Answer 5

Neutropenia

Question 6

Felty’s syndrome is due to?

Answer 6

Neutropenia

Question 7

A drug that induced neutropenia?

Answer 7

Amidopyrine and cephalosphorins

Question 8

5 clinical manifestations of Felty’s syndrome?

Answer 8

“SANTA”
Spenomegaly
Anemia
Neutropenia
Thrombocytopenia
Arthritis

Question 9

Absolute count of eosinophilia?

Answer 9

0.4 x 10^9/L

Question 10

Increased when there is an allergic reactions, pulmonary disorders, gastrointestinal disorders, infections such as scarlet fever, HIV infection, and infestation of tissue-invading parasites?

Answer 10

Eosinophilia

Question 11

Difficult to detect using routine differentials and total leukocyte count?

Answer 11

Eosinopenia

Question 12

This is caused by ACTH administration or Thorn’s test?

Answer 12

Eosinopenia

Question 13

This is a common cause in the presence of malignant myeloproliferative neoplasm?

Answer 13

Basophilia

Question 14

This is associated and relatively a recovery from neutropenia?

Answer 14

Monocytosis

Question 15

Absolute monocyte count of monocytosis?

Answer 15

> 0.9 x 10^9/L

Question 16

A very rare condition of leukopenia that is found in patients receiving steroid therapy?

Answer 16

Monocytopenia

Question 17

Hallmark of pernicious anemia?

Answer 17

Hyepersegmented neutrophil

> 2-5 lobes
polycyte and macropolycyte

Question 18

Termed as disappearance of nucleus or smaller nucleus?

Answer 18

Pyknocyte

Question 19

Virocyte or Atypical Lymphocyte is also known as?

Answer 19

Downey Type Cell and Turk Irritation Cell

Question 20

This cell is activated to respond a viral infection?

Answer 20

Atypical lymphocyte

Question 21

This cell is seen in acute myeloid leukemia (AML)

Answer 21

Reider cell

Question 22

Usually signs of degeneration in severe infections, chemical poisoning, and leukemia?

Answer 22

Vacuolated cell

Question 23

This lymphocyte abnormality is seen in chronic lymphocytic leukemia (CLL)

Answer 23

Basket cell or Smudge cell

Question 24

Cell that can be seen in patients having Systemic Lupus Erythematosus?

Answer 24

L.E. cell

Question 25

PMN which had engulfed the nuclear material of another PMNs or a lymphocyte?

Answer 25

L.E. cell

Question 26

A condition in which monocyte engulfed the nucleus of a lymphocyte or maybe whole lymphocyte itself and this strongly exhibits nucleophagocytosis?

Answer 26

Tart cell

Question 27

This cell exhibits hairy cell leukemia and a type of lymphocyte with hair like cytoplasmic projections?

Answer 27

Hairy cell

Question 28

This cell is commonly seen in a condition called Sezary syndrome and Mycosis fungoides?

Answer 28

Sezary cell

Question 29

This abnormal inclusion body that is classified as always pathological and is spindle in shape and red-purple in color?

Answer 29

Auer bodies/Rods

Question 30

Classified as azurophilic granules?

Answer 30

Auer bodies

Question 31

This inclusion bodies are frequently seen in aplastic anemia and in myelosclerosis?

Answer 31

Toxic granules

Question 32

Inclusion body that stains blue-gray and is usually seen in the periphery of the cytoplasm of neutrophils?

Answer 32

Dohle-Amato bodies

Question 33

Remnants of free ribosomes and mostly seen in bacterial infections, severe burns, exposure to cytotoxic agents, and complicated pregnancies?

Answer 33

Dohle-Amato bodies

Question 34

Inclusion body that is found in the cytoplasm if multiple myeloma and plasma cells after therapy with amidine drugs?

Answer 34

Snapper-Scheid bodies

Question 35

Gamma-globulins bodies that gave a grape or berry or morula cell appearance?

Answer 35

Russel or Fuch's bodies

Question 36

2 groups of leukocyte disorders?

Answer 36

Non-Neoplastic Disorders and Neoplastic and Related Disorders

Question 37

Disorder of nucleus associated with abnormal DNA synthesis and is seen in megaloblastic anemia, it also causes shift to the right?

Answer 37

Hypersegmented neutrophil

Question 38

Decrease segmentation of neutrophil and usually has "pinceness appearance"

Answer 38

Pelger-Guet anomaly

Question 39

This is also known as true or congenital PHA and lamin-B receptor is defected.

Answer 39

Pelger-Huet anomaly

Question 40

Pelger-Huet anomaly is commonly seen in conditions such as?

Answer 40

CML (chronic myelogenous leukemia) and CMDS (chronic myeloproliferative disorder or sydrome)

Question 41

Anomaly that affect all WBC lineage in terms of nuclear shape and chromatin structure?

Answer 41

True-Pelger-Huet anomaly

Question 42

Another type of anomaly that only affects the nucleus of neutrophils and has a less dense nuclei?

Answer 42

Pseudo-Pelger-Huet anomalu

Question 43

Cytoplasm disorder that is usually seen in hunter's syndrome and hurter's syndrome?

Answer 43

Alder-Reily anomaly

Question 44

This has large peroxidase lysosomes inclusions that are deficient in enzymes for phagocytosis. This is also associated with albinism as clinical condition?

Answer 44

Chdiak-Higashi syndrome

Question 45

This is caused by the mutation in the MYH9 gene?

Answer 45

May-Hegglin anomaly

Question 46

Functional disorder in which random movement of phagocytes is normal, but directional motility is impaired.

Answer 46

Job's syndrome

Question 47

Functional disorder of leukocyte that is characterized by both random and directed movement of the cells are defective.

Answer 47

Lazy Leukocyte syndrome

Question 48

Intracellular killing of granulocyte is then defective and usually seen in childhood?

Answer 48

Chronic Granulomatous disease

Question 49

Type of Gaucher's disease characterized by a defect or change in acute neuronopathic and is associated with infancy?

Answer 49

Type 2 Gaucher's disease

Question 50

Type of Gaucher's disease that is characterized by sub-acute neuronopathic and is associated with childhood type?

Answer 50

Type 3 Gaucher's disease

Question 51

It is an inherited leukocyte disorder in which caused by a mutation in the lamin-B receptor?

Answer 51

Pelger-Huet anomaly

Question 52

It is loss of both T and B cells function and is an autosomal recessive disorder?

Answer 52

Swiss-Type Aggamaglobulinema

Question 53

Decrease T-cell production and associated in rare childhood disease and which affects the brain and other parts of the body?

Answer 53

Ataxia Talengiectasia

Question 54

The expected CBC results for women in active labor would be?

Answer 54

High total WBC count with a slight shift to the left in neutrophils