LEUKOTRIENE RECEPTOR ANTAGONIST

Question 1

Leukotriene receptor antagonist

Answer 1

Montelukast (singulair)

Question 2

Leukotriene receptor antagonists function

Answer 2

-Prophylaxis and chronic treatment of asthma in adults and children older than age 12
-NOT meant for management of acute asthmatic attacks
-Montelukast is approved for use in children as young as 12 months and for treatment of allergic rhinitis

Question 3

Leukotriene receptor antagonist drug effects

Answer 3

-By blocking leukotrienes
-Prevents smooth muscle contraction of the bronchial airways
-Decrease mucus secretion
-Prevent vascular permeability
-Decrease neutrophil and leukocyte infiltration to the lungs, preventing inflammation

Question 4

Leukotriene receptor antagonist adverse effects

Answer 4

-Zileuton
-Headache, dyspepsia, nausea, dizziness, insomnia, liver dysfunction
-Zafirlukast
-Headache, nausea, diarrhea, liver dysfunction
-Montelukast has fewer adverse effects (this is why it’s the key drug)
-Depression, suicidal ideation

Question 5

Leukotriene receptor antagonists priority nursing implications

Answer 5

-Oral pill so take daily
-Not for acute asthma
-Monitor mental status
-Longer half-life (takes long to kick in), so keep taking it