Level One Diseases Flashcards
Diseases and Conditions (168 cards)
Parkinson’s Disease: Etiology
Possible causes: infection, drug-induced, idiopathic
Parkinson’s Disease: Disease Process
Chronic progressive neurodegenerative disease affecting CNS
Degeneration of dopaminergic neurons
Excessive acetylcholine accumulates - in a constant excitatory state
Result in akinesia and bradykinesia
Parkinson’s Disease: Life Span
Depends on symptoms and age
Death is typically secondary to complications
Parkinson’s Disease: Characteristics
Resting tremor, rigidity, bradykinesia, postural instability
Gait: loss of arm swing, trunk rotation, shuffling gait, abnormal/uncontroled change in speed
Voice impairments, mask face, pain, visual/spacial issues, hypotension, sleep disturbances
Parkinson’s Disease: Pattern of Progression
Asymmetric onset
Typically see resting tremor in one limb
More symmetrical as disease progresses
Parkinson’s Disease: PT Treatment
Timing of medication and treatment is important
Promote full AROM
Promote BIG movements
Correct kyphotic postures thru extensor strengthening
Balance exercises
Reciprocal movement
Aerobic exercise
Gait retraining - metronome
Medication: Levadopa and Selegiline
- Anixety, depression, GI, dizziness side effects
Parkinson’s Disease: Outcome Measures
Unified Rating Scale for Parkinson’s (UPDRS)
Parkinson’s Disease Questionnaire (PDQ-39)
Hoeh and Yahr
ALS: Disease Process
Progressive motor neuron disease
Gradual deterioration of both UMN and LMN
M>F
A - Amyotrophy = muscle fiber atrophy
L - Lateral = lateral column atrophy
S - Sclerosis = harden/thickening of axons
ALS: Etiology
Unknown (viral, autoimmune, toxic)
Genetic (5-10%)
ALS: Average Life Span
Death within 2-5 years
ALS: Characteristics
Rapidly progressive weakness, muscle atrophy and fasciculations (LMN)
Muscle spasticity and hyperreflexia (UMN)
Difficulty speaking and swallowing (Cranial nerve)
Decline in breathing ability
MSK pain
ALS: Pattern of Progression
Weakness starts peripherally and moves centrally
Muscle groups affects asymmetrically
Gradual involvement of all striated muscles
Bulbar palsy (oral motor dysfunction)
Progress to paralysis w/o remission
Spared: sensory system, cognition, bowel and bladder, autonomic systems
Respiratory system affected later in progression and often cause of death
ALS: PT Treatment
Early: Breathing exercises, maintain activity, functional exercise, mild aerobic exercise, energy conservation, gait aids
Late: Respiratory function, PROM, positioning, skin care, symptom relief, equipment, patient comfort
ALS: Outcome Measures
ALS Functional Rating Scale (ALSFRS) - assess disease progression and function
MS: Disease Process
Chronic, progressive demyelinating disease of CNS
Autoimmune
Damage to myelin sheaths
Impaired neural transmission
Unpredictable
Typically onset of 20-40 years
MS: Etiology
No known cause, most likely viral HLA-DR2
May be genetic link
MS: Average Lifespan
Variable depending on type and severity
Average 5-10 years less than healthy adult
MS: Characteristics
Variability in signs and symptoms depending on location of lesions
Fatigue, muscle weakness, spasticity
Balance issues, paraesthesia, optic neuritis or diplopia
Dizziness and vertigo, ataxia, bowel and bladder issues, impaired cognition, pain, depression
MS: Pattern of progression
Variable course with fluctuations
Progression to permanent dysfunction
4 Types
Exacerbating factors: heat (increases symptoms), stress, pregnancy, infections
MS: PT Treatment
Vestibular rehab, posture, proprioception, core, stretching, cardio, breathing exercises, functional strengthening, coordination, compensatory strategies, gait aid, energy conservation
Late morning sessions
Rest
Medications can be used for spasiticity
MS: Outcome Measues
Multiple Sclerosis Impact Scale
Fatigue Impact Scale
Expanded Disability Status Scale
4 Types of MS
- Relapsing Remitting (85%): clearly defined exacerbations followed by remission, despite remission, permanent damage may be left causing disability over time
- Primary Progressive (10%): slow, gradual worsening of symptoms over time
- Secondary Progressive: initially diagnosed with relapsing-remitting, followed by a steady progression of symptoms in which no periods of remission and symptoms steadily worsen
- Progressive relapsing (5%): steady progression with attacks
Guillain- Barre Syndrome
Autoimmune disease of unknown cause affecting cranial nerves and peripheral nerves
Acute demyelination
Could be triggered by viral infection (experience S&S of infection 3-6 weeks prior to neuro symptoms)
Symmetrical weakness and paresthesias begin in hands and feet and progress proximally
Rapidly progressive (1 day - 2 weeks)
Autonomic system often affected (HR, BP, temp regulation)
Guillain- Barre Syndrome: Recovery and Treatment
Weeks to years, gradual remyelination with good prognosis
1/3 permanent weakness
Early treatment: mechanical ventilation, chest physio (secretion), breathing exercises, education, maintain PROM
Late treatment: functional muscle strengthening, endurance training, gait retraining