Lewis 14 - Transplantation Flashcards
MOA/Class
Prednisone, methylprednisolone
Steroids stabilize leukocytes (WBCs) preventing the release of intracellular chemical/inflammatory mediators
Systemic glucocorticoid/corticosteroid
Tucker 36
Side Effects
Prednisone, methylprednisolone
Growth suppression, elevated blood glucose, weight gain
GI upset (tolerated best in AM with food/milk)
Osteoporosis (long-term use)
Tucker 36
Nursing Considerations
Prednisone, methylprednisolone
Taper dose when stopping to prevent adrenal insufficiency
Tucker 36
Indications
Prednisone, methylprednisolone
Used to decrease inflammation/immune responses.
Tucker 36
MOA/Class
azathioprine, cyclosporine, tacrolimus
Suppresses cell-mediated immunity
Immunosuppressant
Tucker 17
Side Effects
azathioprine, cyclosporine, tacrolimus
Bone marrow suppression. Hepatotoxicity.
Tucker 17
Nursing Considerations
azathioprine, cyclosporine, tacrolimus
Increased risk for infection and cancers. Avoid live-virus vaccines. Good infection control implementation. Avoid grapefruit juice.
Tucker 17
Indications
azathioprine, cyclosporine, tacrolimus
Crohn’s disease/UC, transplant rejection, RA
Tucker 17
MOA/Class
mycophenolate
Inhibits proliferation of B and T lymphocytes
Tucker 17
Side Effects
mycophenolate
Hypertension, GI upset
Tucker 17
Nursing Considerations
mycophenolate
Increased risk for infection and cancers. Avoid live-virus vaccines. Good infection control implementation. Avoid grapefruit juice.
Tucker 17
Indications
mycophenolate
Prevent transplant rejection
Tucker 17
MOA/Class
(-mab)
Action varies with each medication.
Monoclonal antibodies are proteins designed to be attracted to a specific target.
Monoclonal antibodies
Tucker 17
Side Effects
(-mab)
Pulmonary edema, cytokine release syndrome, flu-like symptoms
Tucker 17
Nursing Considerations
(-mab)
May need to pretreat with acetaminophen, diphenhydramine, and/or corticosteroids to manage adverse effects.
May require TB test before starting treatment. Avoid live-virus vaccines.
Tucker 17
