LFTs Flashcards
(30 cards)
what cells produce AST and ALT
hepatocytes
what will an isolated rise in ALT indicate
fatty liver disease
where is GGT produced
hepatocytes and bile ducts
what will an AST:ALT ratio of >2 indicate
alcoholic liver disease
what will cause a rise in GGT
inc in chronic alcohol use, bile duct disease, hepatic mets
where is ALP produced
bile ducts (also bone and placenta)
what will cause an inc in ALP
obs jaundice, bile duct damage
pregnancy
bone disease
what zone of the liver is damaged more by hapatoxic substances
z1 (periorbital)
what zone of the liver is damaged by substances that require bioactovation
z3 (centrilobular)
what will cause a drop in albumin
CLD
malnutrition
sepsis
nephrotic syndrome
what will cause a raise in albumin
acute pancreatitis
what do dilated biliary ducts indicate
gallstones, cancer
when is AFP raised
pregnancy
hepatic damage
hepatocellular carcinoma
what will cause a drop in urobilinogen on a urine dipstick
obs jaundice
what will cause a spike in urobilinogen on a urine dipstick
haemolysis, sepsis, hepatitis
what dye tests are used to assess liver function
indocyanine green
bromosulphaline
what aspects of liver function are dye tests measuring
excretory capacity
hepatic blood flow
what markers are raised following a MI
CLAMT
Ck, LDH, AST, Myoglobin, Troponins
what can you say about the ALT:AST in viral hep
ALT > AST
what can you say about the ALT:AST in alcoholic hep
AST:ALT >2
what will a very raised urea level indicate
kidney failure/dehydration
what will a be raised in chronic liver failure
very high creatinine
what is a shorter term marker for glucose control than HbA1c
fructosamine (3w)
what are some differentials if ALP is raised <5x normal levels
bone tumour/fracture
hepatitis
pregnancy
