Lilley Ch 44 (anti-inflammatory drugs) Flashcards
(18 cards)
Localized protective response stimulated by injury to tissues, which serves to destroy, dilute, or wall off (sequester) both the injurious agent and the injured tissue
inflammation
4 functions of NSAIDs
- analgesic
- antipyretic
- platelet inhibition
- anti-inflammatory
5 chemical categories of NSAIDs
salicylates acetic acid derivatives COX2 inhibitors enolic acid derivatives propionic acid derivatives
NSAID: Shown to reduce cardiac death after myocardial infarction
aspirin
COX pathway: (prostaglandin beneficial body effects) has a role in maintaining the gastrointestinal (GI) mucosa
COX1 (aspirin inhibits)
COX pathway: prostaglandins involved in inflammation
COX2
conditions that are contraindications for NSAID use
peptic ulcer disease
vitamin K deficiency
important adverse effects of NSAIDs to note
- GI bleeding
- acute renal failure
- blackbox warning for heartattack and stroke
- tinnitus
what is low dose aspirin used for
thromboprevention
type of NSAID: inhibits platelet aggregation, antithrombotic effect, ex: aspirin
salicylates
what disease is associated with the use of aspirin while combatting an infection (ex: chickenpox)
reye syndrome
aspirin + acetaminophen + caffeine
excedrin
aspirin-antacid combinations
bufferin
acetic acid derivative: use for PDA, OR/AR, preterm labor
incodin
acetic acid derivative: short term use for pain
toradol
2 examples of propionic acid derivative drugs
ibuprofen
naproxen
only COX2 inhibitor
celebrex (celecoxib)
3 examples of enolic acid derivative drugs, commonly used for patients with arthritis
feldene
mobic
relafen
