Lipid Anabolism (Synthesis) Flashcards
(19 cards)
Common precursor of Triacylglycerols and Phospholipids
Phosphatidic acid
TAGs go back and forth in a cycle between __, __ and __
Adipose tissue, blood, and liver
The key intermediate between glucose, pyruvate and phosphatidic acid is ____
Dihydroxyacetone-Phosphate
To form a phospholipid from phosphatidic acid a ____ must be attached to the phosphate molecule
“Head group” (Example: Serine, Choline, Ethanolamine)
Fatty Acid synthesis takes place in what part of the cell?
Cytoplasm
Fatty acid synthesis occurs in what 2 tissues?
Liver, adipose
A very important enzyme involved in fatty acid synthesis that catalyzes the reverse process that happens in beta-oxidation is ____
Fatty Acid Synthase
The ONE fatty Acid that is synthesized from fatty acid synthase is ____
Palmitate (Palmatidic acid) (16:0)
The enzyme Acetyl-CoA Carboxylase helps synthesize a carbon-3 intermediate known as ______
Malonyl-CoA
Carboxylases are always ____ dependent (Vitamin)
Biotin (B7)
Fatty acid sythase will use __ Acetyl-CoA + __ Malonyl-CoA to synthesize Palmitate
1, 7. Also releases 7 CO2
The electron donor used in Palmitate synthesis is ____
NADPH (4 H+ and 4 e- used in each reaction. So 2 NADPH are used in each reaction.)
To transfer acetyl-CoA from the matrix of the mitochondria to the cytoplasm it must first be combined with ____ to create Citrate so that it can be moved out of the mitochondria
Oxaloacetate (1st step of TCA Cycle)
Coenzyme-A is derived from what vitamin?
Pantothenic Acid (B5)
Citrate Lyase requires how many ATP/Palmitate (in fatty acid synthesis cycle)
8
NAD+ is derived from what vitamin?
Niacin (B3)
Pyruvate carboxylase needs how many ATP/Palmitate (in fatty acid synthesis cycle)?
8
Is a synthase or synthetase directly ATP-Dependent?
Synthetase
In the formation of Malonyl-CoA, Acetyl-CoA Carboxylase needs how many ATP/Palmitate?
7
