Lipid Lowering Drugs

Question 1

Bile acid sequestrants

Answer 1

Cholestyramine
Colestipol
Colesevelam

Question 2

Action of bile acid sequestrants

Answer 2

They increase bile acid synthesis by forming non-absorbable complexes with bile in the intestine

Question 3

What enzyma activity is increased by bile acid resins

Answer 3

7 alpha hydroxylase

Question 4

Bile acid resins increase production of LDL receptor, increasing LDL clearance

Answer 4

True

Question 5

Exetimide MoA

Answer 5

Works by inhibiting the NPC1L1 transporter decreasing uptake of dietary cholesterol

Question 6

In Ezetimide, fat soluble vitamins and drug absorption is not affected

Answer 6

True

Question 7

Reason why Ezetimide has no problem with fat soluble vitamin deficiency

Answer 7

This is because unlike BARs, the don’t affect bile in any way

Question 8

Which of the exogenous drugs have a tendency of vitamin deficiency in vitamins A,D,E&K

Answer 8

BARs (bile acid resins)