Lipid Metabolism

Question 1

What happens to carbohydrates and proteins in excess of the bodies needs?

Answer 1

Converted to fatty acids by the liver

Stored as fats (triaclyglycerols) in adipocytes

Question 2

What do high ATP/ADP cause in the mitochondria?

Answer 2

Inhibition of isocitrate dehydrogenase

Causes increased citrate in mitochondria

Question 3

What converts acetyl CoA into Malonyl-CoA?

Answer 3

Acetyl CoA Carboxylase (ACC)

Question 4

What converts Malonyl-CoA into Fatty acyl-CoA?

Answer 4

Fatty Acyl Synthase (FAS)

Question 5

What moves from the cytoplasm and converted back to acetyl-CoA?

Answer 5

Cirtrate (from Krebs’ Cycle)

Question 6

What is fatty acyl-CoA converted to in order to store fat (energy)?

Answer 6

Triglyceride

Question 7

The liver packages Triglycerides into what vesicle to allow for storage in peripheral tissues?

Answer 7

VLDLs

Question 8

What process involving fatty acids produces large amounts of energy?

Answer 8

Beta-oxidation

Per 2-carbon unit: one FADH2, one NADH and one acetyl-CoA are produced

Question 9

What can be used as an “emergency fuel”?

Answer 9

Ketone bodies produced by the liver