Lipoproteins Flashcards
(34 cards)
Chylomicron: main lipid(s)?
TAG
Chylomicron: apoproteins?
B-48, (A, C, E)
Chylomicron: function(s)?
Transports dietary TAG to adipose, etc (skin, heart, SkM)
Chylomicron Remnant: main lipid(s)?
TAG
Chylomicron Remnant: apoproteins?
B-48, (A, C, E)
Chylomicron Remnant: function(s)?
- Delivers remaining TAG to the liver
- Exchanges TAG for CE from HDL; deliver CE to the liver
VLDL: main lipid(s)?
TAG
VLDL: apoproteins?
B-100, (A, C, E)
VLDL: function(s)?
- Transports endogenously synthesized TAG to adipose tissue and to heart m. + SkM
- Exchanges TAG for CE from HDL
IDL: main lipid(s)?
TAG + cholesterol
IDL: apoproteins?
B-100, E
IDL: function(s)?
- Delivers remaining TAG and cholesterol to the liver
- Exchanges remaining TAG for CE from HDL; deliver CE to the liver
LDL: main lipid(s)?
Cholesterol
LDL: apoproteins?
B-100
LDL: function(s)?
Delivers cholesterol to liver and other cells, including steroidogenic cells
HDL: main lipid(s)?
Cholesterol
HDL: apoproteins?
A’s, (C, E)
HDL: function(s)?
- Accepts cholesterol from peripheral cells, esterifies it, and transports the CEs to the liver
- Exchanges CE for TAG in VLDL, IDL, and chylomicron remnants
- Atheroprotective via enzymes such as paraoxonase that inhibit LDL oxidation
- Serves as a reservoir for circulating apoproteins (A, C, E), which are transported to other lipoprotein particles
Apoprotein B-48: Major LP?
Chylomicron
Apoprotein B-48: Function(s)?
Chylomicron secretion (structural)
Apoprotein B-100: Major LP?
VLDL, IDL, LDL
Apoprotein B-100: Function(s)?
- VLDL and LDL secretion (structural)
- Binds LDL receptor (found on hepatic and non-hepatic tissue)
Apoprotein A-1: Major LP?
HDL
Apoprotein A-1: Function(s)?
- Cofactor for LCAT activation (lecithin cholesterol acyl transferase)
- Binds HDL receptor
