liver Flashcards
(24 cards)
LOFTUS major functions of the liver (6)
- carb metabolism
- protein metabolism
- immune fcn
- lipid metabolism
- vitamin metabolism
- detox & excretion
LOFTUS major type of lipoprotein produced by liver for lipid transport
VLDL
LOFTUS GUACC
glucose urea albumin cholesterol coag = fibrinogen, coag factors
LOFTUS ALP specific to which tissues? location in hepatocyte?
liver, bone, GC induced (dog only)
transmembrane protein
LOFTUS GGT specific to which tissues? location in hepatocyte?
only liver contributes to serum GGT
transmembrane protein
LOFTUS forms and methods of excretion of bilirubin
urobilinogen
stercobilin
LOFTUS DDX for fancones syndrome with liver dz
lepto
Cu associated hepatopathy
LOFTUS DDX for fancones syndrome with liver dz
lepto
Cu associated hepatopathy
LOFTUS DDX for Liver associated ammonia biurate crystals
PSVA
liver failure
LOFTUS types of effusions in abdomen
hemorrhage chyle transudate exudate bile peritonitis uroabdomen
LOFTUS ascites treatments basics
- IVF replacement (avoid 0.9& NaCl)
- avoid NA retaining drugs (GCs, NSAIDs)
- Na wasting diuresis (lasix)
- consider colloids and therapeutic abdcentesis
LOFTUS basic findings in suspected PVSA
- stunted growth
- small liver
- non specific GI signs
- abberant behavior from HE
- UG signs due to stones
- cats only eyes change to Cu colored
LOFTUS tests to run in PSVA suspect
- minimum database
- serum BAs
- coags, prot C
- abd U/S
- baseline cortisol (r/o endocrine?)
LOFTUS pillars of PSVA medical mgmt
- diet change
- lactulose
- antibiotics =(
LOFTUS rank protein sources for medical mgmt of PVSA’s diet
dairy & veg»_space; chicken, eggs, fish»_space;> red meat
LOFTUS basics of liver dz treatment
Vitamin e NAC IV or SAMe PO vitamin k B complex gastroprotectants lactulose - for HE mannitol - for ICP
PRIETO enzymes that promote GB contraction and relaxation and their sources
CCK –> contract from duodenum
somatostatin –> pancreas and gi
PRIETO
PRIETO functions of BAs (3)
emulsify fat
neutralize acid
excretion of cholesterol [and bilirubin]
PRIETO name the two most common canine dzs of the GB
GB mucocele
cholelithiasis
SMITH findings in Cu toxicity of sm rums
methemoglobinuria yellow adipose gun metal kidneys brown mms sequelae of photosensitization
TOMLINSON mechanism of photosensitization in LA with liver dz
chlorophyll from diet normally converted to phylloerythrin (PE) with is conjugated in the LIVER so it can be excreted in BAs.
PE accumulates in skin facilitating formation of free radicals with sunlight
TOMLINSON LA liver leakage enzymes `
SHD
AST
GLDH
TOMLINSON best LA cholestatic enzyme
GGT
