Liver and biliary tree Flashcards

1
Q

Functions of liver

A
Hormone production/breakdown
RBC breakdown
Detoxification 
Bile production 
Glycogen storage 
Albumin production
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2
Q

Where is the liver?

A
RHS of abdomen
Below diaphragm (at T7/8)
Protected by 7-10th ribs
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3
Q

Inferior to liver

A

On RHS is superior pole of right kidney and hepatic colon flexure and adrenal gland

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4
Q

Where is IVC in relation to liver?

A

Posterior

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5
Q

4 lobes of liver

A

Right
left
Caudate
Quadrate

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6
Q

Arterial supply to liver

A

Left gastric, splenic and common hepatic from celiac flexure at T12

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7
Q

Function of hepatic portal vein

A

Transport venous blood to liver

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8
Q

Function of hepatic veins

A

Drain liver of blood

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9
Q

Where do hepatic veins drain to?

A

IVC

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10
Q

3 fissures in liver

A

Left and right sagittal, connected by aorta hepatis

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11
Q

Where is the bile duct?

A

From liver to duodenum

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12
Q

Portal triad

A

Portal vein, hepatic artery and bile duct

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13
Q

How does ductus venous form?

A

Umbilical vein + hepatic portal vein

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14
Q

What does umbilical vein form?

A

Round ligament and ductus venous -> ligamentum venous

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15
Q

How does bile reach its site of action?

A

Channels through r and l hepatic duct to reach common hepatic duct
Common hepatic duct through portal hepatic
Hepatic duct + cystic duct -> common bile duct

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16
Q

Lesser momentum

A

Hepatic vein and artery

17
Q

What is the bare area of the liber?

A

No peritoneum

18
Q

Clinical relevance of hepatorenal and subphrenic recesses

A

Collect fluid
Ascitis - fluid builds up in peritoneal space
Albumin increases oncotic pressure of blood

19
Q

Where does the falciform ligament run?

A

Abdominal wall to liver

20
Q

Where are the triangular ligaments?

A

They travel towards diaphragm

21
Q

Where are the coronary ligaments?

A

From peritoneum to diaphragm

22
Q

Liver failure sx

A
  • Clubbing
  • Spider neavi
  • Palmer erythema
  • Encephalopathy
  • Asterixis
  • Gynecomastica
  • Bruising
  • Xanthoma
23
Q

Gall stones

A
  • Gall stones: collection of cholesterol in gall bladder
  • Normally gall bladder squeezes stones towards duodenum and scrape lining of biliary tree
  • Gall stones have normal obs, just pain in RUQ
  • If stone lodges in cystic duct forms back up of bile into gall bladder, distending it and causing bacteria to grow (cholecystitis)
24
Q

What is cholecystitis

A

Gall stone lodges in cystic duct and creates back up of bile into gall bladder

25
Is there jaundice with cholecystitis and why
- Cholecystitis unlikely to be jaundiced - Bilirubin is breakdown product and excreted in bile fluid - Bilirubin can be excreted in cystitis so no jaundice
26
Ascending cholangitis
Ascending cholangitis: stone blocked in bile duct - bile builds up in liver and bilirubin builds up in blood causing jaundice
27
Charcot's triad
Fever, jaundice, abdominal pain
28
Symptoms of pancreatic cancer
Painless jaundice
29
What shape are liver lobules?
Hexagonal
30
Which three things are found between liver lobules
Portal vein, artery and bile duct
31
What is found in the centre of liver lobules?
Central vein
32
What communicates between the centre and edge of lobules
Sinusoids and hepatocytes
33
Where does bile move in the liver lobules?
To bile duct in portal triad
34
Function of stellate cells
Stellate cells secrete collagen (hepatocytes damaged in cirrhosis for example)
35
Asterixis
Liver failure due to build up of toxins = flapping hands
36
Does oestrogen increase or decrease in liver failure?
Increase
37
Why is collagen bad?
- Collagen narrows channels to stop blood running to central vein → build up of bile - Blood can't get through liver - back up of blood in portal venous system